Function and structure relationships of a β‐1,2‐glucooligosaccharide‐degrading β‐glucosidase
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12911
Abstract: BT_3567 protein, a putative β‐glucosidase from Bacteroides thetaiotaomicron, exhibits higher activity toward Sop3–5 (Sopn, n: degree of polymerization of β‐1,2‐glucooligosaccharides) than toward Sop2, unlike a known β‐glucosidase from Listeria innocua which predominantly prefers Sop2. In… read more here.
Keywords: relationships glucooligosaccharide; glucooligosaccharide degrading; structure relationships; function structure ... See more keywords
Design and Synthesis of β‐Carboline Hydrazone Hybrids as New α‐Amylase and α‐Glucosidase Inhibitors: Inhibition Kinetics and Molecular Docking Studies
Sign Up to like & getrecommendations! Published in 2025 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.202500365
Abstract: Diabetes mellitus (DM) is a chronic metabolic disorder that has been flagged as a global threat with progression at an alarming rate worldwide. The dual inhibition of carbohydrate hydrolases, α‐amylase, and α‐glucosidase, has been considered… read more here.
Keywords: hybrids new; carboline hydrazone; amylase glucosidase; hydrazone hybrids ... See more keywords
Bioevaluation of synthetic pyridones as dual inhibitors of α‐amylase and α‐glucosidase enzymes and potential antioxidants
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DOI: 10.1002/ardp.202200400
Abstract: Herein, a library of novel pyridone derivatives 1–34 was designed, synthesized, and evaluated for α‐amylase and α‐glucosidase inhibitory as well as antioxidant activities. Pyridone derivatives 1–34 were synthesized via a one‐pot multi‐component reaction of variously… read more here.
Keywords: bioevaluation synthetic; glucosidase; pyridones dual; amylase glucosidase ... See more keywords
Pyrazole scaffold‐based derivatives: A glimpse of α‐glucosidase inhibitory activity, SAR, and route of synthesis
Sign Up to like & getrecommendations! Published in 2023 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200421
Abstract: The α‐glucosidase is a validated target to develop drugs for treating type 2 diabetes mellitus. The existing α‐glucosidase inhibitors have certain shortcomings related to side effects and route of synthesis. Accordingly, it is inevitable to… read more here.
Keywords: glucosidase; synthesis; glucosidase inhibitors; activity ... See more keywords
Synthesis of 1,2,3-triazole-1,3,4-thiadiazole hybrids as novel α-glucosidase inhibitors by in situ azidation/click assembly.
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DOI: 10.1002/ardp.202300145
Abstract: α-Glucosidase inhibition is widely used in the oral management of diabetes mellitus (DM), a disease characterized by high blood sugar levels (hyperglycemia) and abnormal carbohydrate metabolism. In this respect, a series of 1,2,3-triazole-1,3,4-thiadiazole hybrids 7a-j… read more here.
Keywords: glucosidase; triazole thiadiazole; click assembly; thiadiazole hybrids ... See more keywords
Covalent Immobilization of β‐Glucosidase on Magnetic Spent Coffee Grounds Modified With PAMAM Dendrimers for Enhanced Glucose Tolerance
Sign Up to like & getrecommendations! Published in 2025 at "Biotechnology Journal"
DOI: 10.1002/biot.70025
Abstract: The successful application of enzymes in industries encounters challenges related to high costs, stability, and reuse. In this study, β‐glucosidase (BGL) was immobilized via a covalent method after the synthesis of different generations (G0‐2) of… read more here.
Keywords: covalent; pamam dendrimers; coffee grounds; spent coffee ... See more keywords
Divergent Synthesis of Novel 3(5)‐Aminoazole–Benzopyrone Hybrids and their Evaluation as α‐Glucosidase Inhibitors
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DOI: 10.1002/cmdc.202400525
Abstract: An efficient approach has been developed for the trapping in situ generated benzopyrone‐based ortho‐quinone methide intermediates by 3‐ and 5‐amino pyrazoles or isoxazoles. In cases of naturally occurring phenolic Mannich bases, hybrid compounds between the azole… read more here.
Keywords: synthesis novel; aminoazole benzopyrone; divergent synthesis; glucosidase ... See more keywords
Synthesis of benzimidazole based hydrazones as non-sugar based α-glucosidase inhibitors: Structure activity relation and molecular docking.
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DOI: 10.1002/ddr.21807
Abstract: In search for α-glucosidase inhibitors used in the treatment of diabetes mellitus, a series of unique benzimidazole based hydrazones derivatives were synthesized (5a-5p), which were then investigated for their in vitro α-glucosidase inhibitory potential. The… read more here.
Keywords: benzimidazole based; glucosidase inhibitors; based hydrazones; structure ... See more keywords
α‐Glucosidase inhibitory effect of an anthraquinonoid produced by Fusarium incarnatum GDZZ‐G2
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DOI: 10.1002/jobm.202200166
Abstract: α‐Glucosidase is the key enzyme on carbohydrate metabolism, and its bioactive inhibitors are supposed to be an effective therapeutic for type 2 diabetes mellitus. During our continuing study for discovering α‐glucosidase inhibitors, a fungus GDZZ‐G2… read more here.
Keywords: compound; inhibitory effect; glucosidase; fusarium incarnatum ... See more keywords
Use of a purified β-glucosidase from microorganisms associated coral to enhance wine aroma.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.11694
Abstract: BACKGROUND Beta-Glucosidases (3.2.1.21) play essential roles in the removal of nonreducing terminal glucosyl residues from saccharides and glycosides. However, the full potential and different applications of recombinant high-yield microbial β-glucosidase-producing systems remain to be tackled.… read more here.
Keywords: use purified; purified glucosidase; wine; glucosidase microorganisms ... See more keywords
Extraction optimization, physicochemical property, antioxidant activity and α-glucosidase inhibitory effect of polysaccharides from lotus seedpods.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.11755
Abstract: BACKGROUND Lotus seedpods is the agricultural by-products of lotus (Nelumbo nucifera Gaertn.), which is widely cultivated in Southeast Asia and Australia. Most of lotus seedpods are considered wastes which are abandoned and incinerated, resulting in… read more here.
Keywords: lotus seedpods; inhibitory effect; glucosidase; extraction ... See more keywords