Function and structure relationships of a β‐1,2‐glucooligosaccharide‐degrading β‐glucosidase
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12911
Abstract: BT_3567 protein, a putative β‐glucosidase from Bacteroides thetaiotaomicron, exhibits higher activity toward Sop3–5 (Sopn, n: degree of polymerization of β‐1,2‐glucooligosaccharides) than toward Sop2, unlike a known β‐glucosidase from Listeria innocua which predominantly prefers Sop2. In… read more here.
Keywords: relationships glucooligosaccharide; glucooligosaccharide degrading; structure relationships; function structure ... See more keywords
Bioevaluation of synthetic pyridones as dual inhibitors of α‐amylase and α‐glucosidase enzymes and potential antioxidants
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DOI: 10.1002/ardp.202200400
Abstract: Herein, a library of novel pyridone derivatives 1–34 was designed, synthesized, and evaluated for α‐amylase and α‐glucosidase inhibitory as well as antioxidant activities. Pyridone derivatives 1–34 were synthesized via a one‐pot multi‐component reaction of variously… read more here.
Keywords: bioevaluation synthetic; glucosidase; pyridones dual; amylase glucosidase ... See more keywords
Pyrazole scaffold‐based derivatives: A glimpse of α‐glucosidase inhibitory activity, SAR, and route of synthesis
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DOI: 10.1002/ardp.202200421
Abstract: The α‐glucosidase is a validated target to develop drugs for treating type 2 diabetes mellitus. The existing α‐glucosidase inhibitors have certain shortcomings related to side effects and route of synthesis. Accordingly, it is inevitable to… read more here.
Keywords: glucosidase; synthesis; glucosidase inhibitors; activity ... See more keywords
Synthesis of 1,2,3-triazole-1,3,4-thiadiazole hybrids as novel α-glucosidase inhibitors by in situ azidation/click assembly.
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DOI: 10.1002/ardp.202300145
Abstract: α-Glucosidase inhibition is widely used in the oral management of diabetes mellitus (DM), a disease characterized by high blood sugar levels (hyperglycemia) and abnormal carbohydrate metabolism. In this respect, a series of 1,2,3-triazole-1,3,4-thiadiazole hybrids 7a-j… read more here.
Keywords: glucosidase; triazole thiadiazole; click assembly; thiadiazole hybrids ... See more keywords
Synthesis of benzimidazole based hydrazones as non-sugar based α-glucosidase inhibitors: Structure activity relation and molecular docking.
Sign Up to like & getrecommendations! Published in 2021 at "Drug development research"
DOI: 10.1002/ddr.21807
Abstract: In search for α-glucosidase inhibitors used in the treatment of diabetes mellitus, a series of unique benzimidazole based hydrazones derivatives were synthesized (5a-5p), which were then investigated for their in vitro α-glucosidase inhibitory potential. The… read more here.
Keywords: benzimidazole based; glucosidase inhibitors; based hydrazones; structure ... See more keywords
α‐Glucosidase inhibitory effect of an anthraquinonoid produced by Fusarium incarnatum GDZZ‐G2
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Basic Microbiology"
DOI: 10.1002/jobm.202200166
Abstract: α‐Glucosidase is the key enzyme on carbohydrate metabolism, and its bioactive inhibitors are supposed to be an effective therapeutic for type 2 diabetes mellitus. During our continuing study for discovering α‐glucosidase inhibitors, a fungus GDZZ‐G2… read more here.
Keywords: compound; inhibitory effect; glucosidase; fusarium incarnatum ... See more keywords
Use of a purified β-glucosidase from microorganisms associated coral to enhance wine aroma.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.11694
Abstract: BACKGROUND Beta-Glucosidases (3.2.1.21) play essential roles in the removal of nonreducing terminal glucosyl residues from saccharides and glycosides. However, the full potential and different applications of recombinant high-yield microbial β-glucosidase-producing systems remain to be tackled.… read more here.
Keywords: use purified; purified glucosidase; wine; glucosidase microorganisms ... See more keywords
Extraction optimization, physicochemical property, antioxidant activity and α-glucosidase inhibitory effect of polysaccharides from lotus seedpods.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.11755
Abstract: BACKGROUND Lotus seedpods is the agricultural by-products of lotus (Nelumbo nucifera Gaertn.), which is widely cultivated in Southeast Asia and Australia. Most of lotus seedpods are considered wastes which are abandoned and incinerated, resulting in… read more here.
Keywords: lotus seedpods; inhibitory effect; glucosidase; extraction ... See more keywords
Inhibitory potential of phenolic compounds of Thai colored rice (Oryza sativa L.) against α-glucosidase and α-amylase through in vitro and in silico studies.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12039
Abstract: BACKGROUND This study investigated the inhibitory efficiency of phenolic compounds content methyl vanillate, syringic acid and vanillic acid against α-glucosidase and α-amylase. The phenolic compound contents of ten Thai colored rice cultivars were also determined,… read more here.
Keywords: glucosidase amylase; glucosidase; phenolic compounds; colored rice ... See more keywords
Investigating inhibitory activity of novel synthetic sericin peptide on α-D-glucosidase: kinetics and interaction mechanism study using a docking simulation.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.8620
Abstract: BACKGROUND We synthesised a novel sericin peptide (SP-GI) with α-d-glucosidase inhibitory activity, which has a sequence of SEDSSEVDIDLGN. The kinetics of its peptide-induced inhibition on α-d-glucosidase activity and its interaction mechanism merging with molecular docking… read more here.
Keywords: mechanism; sericin peptide; interaction; glucosidase ... See more keywords
Comparative α-glucosidase and α-amylase inhibition studies of rhodanine–pyrazole conjugates and their simple rhodanine analogues
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DOI: 10.1007/s00044-018-2272-z
Abstract: Novel rhodanine–pyrazole conjugates (6a–i) and their simple rhodanine analogues (8a–e) were prepared and comparatively screened for their antidiabetic activities against enzymatic targets, α-glucosidase and α-amylase. As expected, the molecular hybrids exhibited significantly greater inhibitory activity… read more here.
Keywords: rhodanine; simple rhodanine; rhodanine pyrazole; conjugates simple ... See more keywords