Inhibitory potential of phenolic compounds of Thai colored rice (Oryza sativa L.) against α-glucosidase and α-amylase through in vitro and in silico studies.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12039
Abstract: BACKGROUND This study investigated the inhibitory efficiency of phenolic compounds content methyl vanillate, syringic acid and vanillic acid against α-glucosidase and α-amylase. The phenolic compound contents of ten Thai colored rice cultivars were also determined,… read more here.
Keywords: glucosidase amylase; glucosidase; phenolic compounds; colored rice ... See more keywords
Novel cinnamic acid magnolol derivatives as potent α-glucosidase and α-amylase inhibitors: Synthesis, in vitro and in silico studies.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105291
Abstract: In this study, twenty novel cinnamic acid magnolol derivatives were synthesized, and screened for their anti-hyperglycemic potential. All synthesized compounds exhibited good to moderate α-glucosidase and α-amylase inhibitory activities with IC50 values: 5.11 ± 1.46-90.26 ± 1.85 µM and 4.27 ± 1.51-49.28 ± 2.54 µM… read more here.
Keywords: novel cinnamic; cinnamic acid; magnolol derivatives; glucosidase amylase ... See more keywords
Exploring efficacy of indole-based dual inhibitors for α-glucosidase and α-amylase enzymes: In silico, biochemical and kinetic studies.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.03.090
Abstract: α-Glucosidase and α-amylase are enzymes which are associated with diabetic II. These enzymes break macromolecules of sugar into monosugar molecules which is soluble in body, hence increase the sugar level in blood. There is need… read more here.
Keywords: exploring efficacy; glucosidase amylase; amylase enzymes; efficacy indole ... See more keywords
Antidiabetic potential of Catechu via assays for α-glucosidase, α-amylase, and glucose uptake in adipocytes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2022.115118
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Catechu is the dry water extract of barked branches or stems from Senegalia catechu(L. F.)P. J. H. Hurter & Mabb, which is used as a hypoglycemic regulator in recent researches. Potential anti-hyperglycemic components… read more here.
Keywords: glucosidase amylase; kcal mol; glucose uptake; catechu ... See more keywords
Seperation, characterization and inhibition on α-glucosidase, α-amylase and glycation of a polysaccharide from blackcurrant fruits
Sign Up to like & getrecommendations! Published in 2018 at "Lwt - Food Science and Technology"
DOI: 10.1016/j.lwt.2018.03.023
Abstract: Abstract A heteropolysaccharide BCP-2 was isolated from blackcurrant fruits by successively using D4006 resin, aqueous two phase system, and Sephadex G-100 column chromatography. Its inhibitory activities against α-glucosidase, α-amylase and glycation were investigated. BCP-2 was… read more here.
Keywords: blackcurrant fruits; glucosidase amylase; amylase glycation; bcp ... See more keywords
Inhibitory effect of roasted/ unroasted Argania spinosa seeds oil on α- glucosidase, α-amylase and intestinal glucose absorption activities
Sign Up to like & getrecommendations! Published in 2020 at "South African Journal of Botany"
DOI: 10.1016/j.sajb.2020.09.020
Abstract: Abstract Background Diabetes mellitus is a serious metabolic disease, which affects a large number of populations in the world. Phytotherapy is considered as the most remedies used by Moroccan people to treat this pathology. Argania… read more here.
Keywords: absorption; amylase intestinal; glucosidase amylase; effect ... See more keywords
Postprandial Hyperglycemia Lowering Effect of the Isolated Compounds from Olive Mill Wastes – An Inhibitory Activity and Kinetics Studies on α-Glucosidase and α-Amylase Enzymes
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c01622
Abstract: In the present study, we isolated seven compounds from olive mill wastes (OMW), one of them being novel, and investigated their antidiabetic potential through inhibition of α-glucosidase and α-amylase enzymes. To assist the possible characterization… read more here.
Keywords: mill wastes; compounds olive; glucosidase amylase; amylase enzymes ... See more keywords
Molecular Modeling and Synthesis of Indoline-2,3-dione-Based Benzene Sulfonamide Derivatives and Their Inhibitory Activity against α-Glucosidase and α-Amylase Enzymes
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.3c01130
Abstract: Diabetes is also known as a critical and noisy disease. Hyperglycemia, that is, increased blood glucose level is a common effect of uncontrolled diabetes, and over a period of time can cause serious effects on… read more here.
Keywords: glucosidase amylase; amylase; dione based; based benzene ... See more keywords
Metabolite profiling and inhibitory properties of leaf extracts of Ficus benjamina towards α-glucosidase and α-amylase
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Food Properties"
DOI: 10.1080/10942912.2018.1499112
Abstract: ABSTRACT The use of antioxidant-rich medicinal plants having the potential to reduce oxidative stress and postprandial hyperglycemic pressure is one of the most promising option for the management of diabetes. This study presents information on… read more here.
Keywords: leaf extracts; glucosidase amylase; metabolite profiling; inhibitory properties ... See more keywords
Synthesis and bioactivities evaluation of oleanolic acid oxime ester derivatives as α-glucosidase and α-amylase inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2021.2018682
Abstract: Abstract Different oleanolic acid (OA) oxime ester derivatives (3a-3t) were designed and synthesised to develop inhibitors against α-glucosidase and α-amylase. All the synthesised OA derivatives were evaluated against α-glucosidase and α-amylase in vitro. Among them,… read more here.
Keywords: glucosidase amylase; ester derivatives; amylase; acid oxime ... See more keywords
Inhibitory Effect of Five Ganoderma Species (Agaricomycetes) against Key Digestive Enzymes Related to Type 2 Diabetes Mellitus.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of medicinal mushrooms"
DOI: 10.1615/intjmedmushrooms.v21.i7.70
Abstract: Ganoderma mushrooms are widely used in clinical therapies and functional foods. The antidiabetic effect of Ganoderma has become a research hot spot in recent decades. To search for a superior antidiabetic Ganoderma extract, five common… read more here.
Keywords: inhibitory effect; five ganoderma; ganoderma species; glucosidase amylase ... See more keywords