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Published in 2023 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200421
Abstract: The α‐glucosidase is a validated target to develop drugs for treating type 2 diabetes mellitus. The existing α‐glucosidase inhibitors have certain shortcomings related to side effects and route of synthesis. Accordingly, it is inevitable to…
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Keywords:
glucosidase;
synthesis;
glucosidase inhibitors;
activity ... See more keywords
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Published in 2021 at "Drug development research"
DOI: 10.1002/ddr.21807
Abstract: In search for α-glucosidase inhibitors used in the treatment of diabetes mellitus, a series of unique benzimidazole based hydrazones derivatives were synthesized (5a-5p), which were then investigated for their in vitro α-glucosidase inhibitory potential. The…
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Keywords:
benzimidazole based;
glucosidase inhibitors;
based hydrazones;
structure ... See more keywords
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Published in 2017 at "Journal of separation science"
DOI: 10.1002/jssc.201700258
Abstract: The separation of a compound of interest from its structurally similar homologues to produce high-purity natural products is a challenging problem. This work proposes a novel method for the separation of iristectorigenin A from its…
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Keywords:
extraction;
ionic liquid;
liquid;
glucosidase inhibitors ... See more keywords
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Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-2112-6
Abstract: Synthesis of indolyl linked benzylidene-based para-substituted phenyl containing thiazolidinediones and acyclic analogs of isoxazolidinediones—a cyclic analog of thiazolidinedione (4a–7b) in an effort to develop novel α-glucosidase inhibitors in the management of hyperglycemia for the treatment…
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Keywords:
para substituted;
benzylidene based;
phenyl containing;
glucosidase inhibitors ... See more keywords
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Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-05145-3
Abstract: Diabetes is considered as a major health concern worldwide and patients with diabetes are at high risk for infectious diseases. Therefore, α-glucosidase inhibitors possessing antibacterial activity along with the ability to inhibit biofilms would be…
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Keywords:
endophytic fungus;
antimicrobial antibiofilm;
alternaria destruens;
glucosidase inhibitors ... See more keywords
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Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103182
Abstract: Diabetes is a non-communicable disease, which occurs either due to the lack of insulin or the inability of the human body to recognize it. The recent data indicates an increase in the trend of people…
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Keywords:
new class;
novel fluorophenyl;
glucosidase inhibitors;
glucosidase ... See more keywords
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Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105423
Abstract: In the present study, a series of 2-phenyl-1H-benzo[d]imidazole-based α-glucosidase inhibitors were synthesized and evaluated for their in vitro and in vivo anti-diabetic potential. Screening of an in-house library revealed a moderated α-glucosidase inhibitor, 6a with…
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Keywords:
phenyl benzo;
vivo anti;
glucosidase inhibitors;
study ... See more keywords
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Published in 2018 at "Current opinion in food science"
DOI: 10.1016/j.cofs.2018.02.008
Abstract: The ageing population, together with unhealthy diets, physical inactivity and obesity are the main drivers of the increased prevalence of Type 2 diabetes mellitus (T2DM). Apart from pharmacological treatments, the food industries can play a…
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Keywords:
food derived;
glucosidase inhibitors;
food;
structure ... See more keywords
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Published in 2020 at "Fitoterapia"
DOI: 10.1016/j.fitote.2020.104522
Abstract: Worldwide, 463 million people are affected by diabetes of which the majority is diagnosed with Type 2 Diabetes (T2D). T2D can ultimately lead to retinopathy, nephropathy, nerve damage, and amputation of the lower extremities. α-Glucosidase,…
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Keywords:
endophytic penicillium;
penicillium canescens;
inhibitory activities;
glucosidase inhibitors ... See more keywords
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Published in 2021 at "Food chemistry"
DOI: 10.1016/j.foodchem.2021.131306
Abstract: Brown rice bound phenolics extracts (BRBPE) have been reported to possess α-glucosidase inhibitory effects, the specific enzyme inhibitors involved in this process were unknown. Here, α-glucosidase inhibitors in BRBPE were screened using bioaffinity ultrafiltration methods,…
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Keywords:
rice bound;
bound phenolics;
glucosidase inhibitors;
brown rice ... See more keywords
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Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114618
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Syzygium polyanthum (Wight) Walp leaves are traditionally used to cure diabetes in many regions of Indonesia. Traditional use involves boiling the leaves until the water is reduced to half volume, and then the…
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Keywords:
polyanthum wight;
analysis;
activity;
glucosidase inhibitors ... See more keywords