Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors
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DOI: 10.3390/molecules24020354
Abstract: A series of simple C-alkyl pyrrolidines already known as cytotoxic inhibitors of ceramide glucosylation in melanoma cells can be converted into their corresponding 6-membered analogues by means of a simple ring expansion. This study illustrated… read more here.
Keywords: iminosugar; glucosylceramide ceramide; selective targeting; targeting interconversion ... See more keywords