4‐O‐Substituted Glucuronic Cyclophellitols are Selective Mechanism‐Based Heparanase Inhibitors
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DOI: 10.1002/cmdc.202200580
Abstract: Degradation of the extracellular matrix (ECM) supports tissue integrity and homeostasis, but is also a key factor in cancer metastasis. Heparanase (HPSE) is a mammalian ECM‐remodeling enzyme with β‐D‐endo‐glucuronidase activity overexpressed in several malignancies, and… read more here.
Keywords: substituted glucuronic; hpse; glucuronic cyclophellitols; cyclophellitols selective ... See more keywords