Alkyne‐ and azide‐functionalised cyclophellitol derivatives for selective glucuronidase targeting
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202401076
Abstract: Heparanase is an endo‐acting β‐glucuronidase and the only known enzyme responsible for the regulation of heparan sulfate structures in the extracellular matrix. The enzyme is found to be significantly upregulated in aggressive cancer types, aiding… read more here.
Keywords: functionalised cyclophellitol; cyclophellitol derivatives; glucuronidase; derivatives selective ... See more keywords
High-Throughput Screening of Chemical Compound Libraries for Modulators of Salicylic Acid Signaling by In Situ Monitoring of Glucuronidase-Based Reporter Gene Expression.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7874-8_5
Abstract: Salicylic acid (SA) is a vital phytohormone that is intimately involved in coordination of the complex plant defense response to pathogen attack. Many aspects of SA signaling have been unraveled by classical genetic and biochemical… read more here.
Keywords: reporter; methodology; salicylic acid; reporter gene ... See more keywords
Recent advances of sensing strategies for the detection of β-glucuronidase activity
Sign Up to like & getrecommendations! Published in 2022 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-022-03921-y
Abstract: β-Glucuronidase (β-GLU), a kind of hydrolase, is widely distributed in mammalian tissues, body fluids, and microbiota. Abnormal changes of β-GLU activity are often correlated with the occurrence of diseases and deterioration of water quality. Therefore,… read more here.
Keywords: chemistry; detection; glucuronidase; activity ... See more keywords
Increased activity of β-glucuronidase variants produced by site-directed mutagenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2017.09.005
Abstract: β-glucuronidase (BGus) is an essential glycosyl hydrolase which has been widely used in biological and biomedical applications. In this paper, we report the construction and screening of nineteen Escherichia coli BGus (EBGus) mutants using site-directed… read more here.
Keywords: directed mutagenesis; site; glucuronidase; site directed ... See more keywords
The study of inhibitory effect of natural flavonoids toward β-glucuronidase and interaction of flavonoids with β-glucuronidase.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.12.057
Abstract: β-Glucuronidase plays a vital role in the metabolism of drug and endogenous substance. Herein, we assayed the inhibitory effects of thirty-six flavonoids (1-36) toward β-glucuronidase (Escherichia coli) using the probe reaction of DDAO-glu hydrolysis. The… read more here.
Keywords: natural flavonoids; toward glucuronidase; flavonoids toward; glucuronidase ... See more keywords
Purification and characterization of a novel β-glucuronidase precisely converts glycyrrhizin to glycyrrhetinic acid 3-O-mono-β-D-glucuronide from plant endophytic Chaetomium globosum DX-THS3.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.05.047
Abstract: Glycyrrhetinic acid monoglucuronide (GAMG) is an innovative functional sweetener with higher sweetness and stronger pharmacological activity than glycyrrhizin (GL). A novel β-glucuronidase (cg-GUS) was firstly screened from plant endophytic fungus Chaetomium globosum DX-THS3. The cg-GUS… read more here.
Keywords: glycyrrhetinic acid; plant endophytic; glycyrrhizin; glucuronidase ... See more keywords
Prenylflavonoids sanggenon C and kuwanon G from mulberry (Morus alba L.) as potent broad-spectrum bacterial β-glucuronidase inhibitors: Biological evaluation and molecular docking studies
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2018.07.013
Abstract: Abstract Gut microbial β-glucuronidases show varied substrate specificity and inhibition propensity, highlighting the necessity of discovering broad-spectrum β-glucuronidase inhibitor to meet clinical needs. In this study, two prenylflavonoids sanggenon C (SGC) and kuwanon G (KWG)… read more here.
Keywords: prenylflavonoids sanggenon; inhibition; glucuronidase; broad spectrum ... See more keywords
Comparative Study on Covalent and Noncovalent Endogenous Albumin-Binding β-Glucuronidase-Activated SN38 Prodrugs for Antitumor Efficacy.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c03096
Abstract: Albumin-binding prodrugs have been explored to overcome the limitations of small-molecule anticancer chemotherapy agents, such as inadequate physiological and pharmaceutical compatibility, as well as rapid renal clearance. Herein, we investigated two endogenous albumin-binding prodrugs, M-g-SN38… read more here.
Keywords: antitumor efficacy; albumin binding; glucuronidase; endogenous albumin ... See more keywords
In vitro and in vivo studies on the metabolism and pharmacokinetics of the selective gut microbial β-glucuronidase targeting compound Inh 1
Sign Up to like & getrecommendations! Published in 2024 at "Xenobiotica"
DOI: 10.1080/00498254.2024.2357765
Abstract: Abstract In vitro studies using rat, mouse, and human microsomes and hepatocytes on the bacterial β-glucuronidase inhibitor 1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(4-ethoxyphenyl)-1-(2-hydroxyethyl)thiourea) (Inh 1) revealed extensive metabolism in all species. The intrinsic clearances of Inh 1 in human, mouse,… read more here.
Keywords: glucuronidase; mouse rat; inh; mouse ... See more keywords
Fecal β-glucuronidase activity differs between hematopoietic cell and kidney transplantation and a possible mechanism for disparate dose requirements
Sign Up to like & getrecommendations! Published in 2022 at "Gut Microbes"
DOI: 10.1080/19490976.2022.2108279
Abstract: ABSTRACT The intestinal microbiota produces β-glucuronidase that plays an essential role in the metabolism of the immunosuppressant mycophenolate mofetil (MMF). This drug is commonly used in organ and hematopoietic cell transplantation (HCT), with variations in… read more here.
Keywords: glucuronidase activity; kidney; hematopoietic cell; activity differs ... See more keywords
Association of ß-glucuronidase activity with menopausal status, ethnicity, adiposity, and inflammation in women
Sign Up to like & getrecommendations! Published in 2023 at "Menopause"
DOI: 10.1097/gme.0000000000002106
Abstract: β-Glucuronidase was positively associated with Hispanic ethnicity, C-reactive protein, body mass index and total fat mass, but not menopausal status nor lean mass, with future studies required to understand mechanistic underpinnings for these findings. Abstract… read more here.
Keywords: activity; menopausal status; glucuronidase; ethnicity ... See more keywords