High-Throughput Screening of Chemical Compound Libraries for Modulators of Salicylic Acid Signaling by In Situ Monitoring of Glucuronidase-Based Reporter Gene Expression.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7874-8_5
Abstract: Salicylic acid (SA) is a vital phytohormone that is intimately involved in coordination of the complex plant defense response to pathogen attack. Many aspects of SA signaling have been unraveled by classical genetic and biochemical… read more here.
Keywords: reporter; methodology; salicylic acid; reporter gene ... See more keywords
Recent advances of sensing strategies for the detection of β-glucuronidase activity
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DOI: 10.1007/s00216-022-03921-y
Abstract: β-Glucuronidase (β-GLU), a kind of hydrolase, is widely distributed in mammalian tissues, body fluids, and microbiota. Abnormal changes of β-GLU activity are often correlated with the occurrence of diseases and deterioration of water quality. Therefore,… read more here.
Keywords: chemistry; detection; glucuronidase; activity ... See more keywords
Increased activity of β-glucuronidase variants produced by site-directed mutagenesis.
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DOI: 10.1016/j.enzmictec.2017.09.005
Abstract: β-glucuronidase (BGus) is an essential glycosyl hydrolase which has been widely used in biological and biomedical applications. In this paper, we report the construction and screening of nineteen Escherichia coli BGus (EBGus) mutants using site-directed… read more here.
Keywords: directed mutagenesis; site; glucuronidase; site directed ... See more keywords
The study of inhibitory effect of natural flavonoids toward β-glucuronidase and interaction of flavonoids with β-glucuronidase.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.12.057
Abstract: β-Glucuronidase plays a vital role in the metabolism of drug and endogenous substance. Herein, we assayed the inhibitory effects of thirty-six flavonoids (1-36) toward β-glucuronidase (Escherichia coli) using the probe reaction of DDAO-glu hydrolysis. The… read more here.
Keywords: natural flavonoids; toward glucuronidase; flavonoids toward; glucuronidase ... See more keywords
Purification and characterization of a novel β-glucuronidase precisely converts glycyrrhizin to glycyrrhetinic acid 3-O-mono-β-D-glucuronide from plant endophytic Chaetomium globosum DX-THS3.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.05.047
Abstract: Glycyrrhetinic acid monoglucuronide (GAMG) is an innovative functional sweetener with higher sweetness and stronger pharmacological activity than glycyrrhizin (GL). A novel β-glucuronidase (cg-GUS) was firstly screened from plant endophytic fungus Chaetomium globosum DX-THS3. The cg-GUS… read more here.
Keywords: glycyrrhetinic acid; plant endophytic; glycyrrhizin; glucuronidase ... See more keywords
Prenylflavonoids sanggenon C and kuwanon G from mulberry (Morus alba L.) as potent broad-spectrum bacterial β-glucuronidase inhibitors: Biological evaluation and molecular docking studies
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DOI: 10.1016/j.jff.2018.07.013
Abstract: Abstract Gut microbial β-glucuronidases show varied substrate specificity and inhibition propensity, highlighting the necessity of discovering broad-spectrum β-glucuronidase inhibitor to meet clinical needs. In this study, two prenylflavonoids sanggenon C (SGC) and kuwanon G (KWG)… read more here.
Keywords: prenylflavonoids sanggenon; inhibition; glucuronidase; broad spectrum ... See more keywords
Fecal β-glucuronidase activity differs between hematopoietic cell and kidney transplantation and a possible mechanism for disparate dose requirements
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DOI: 10.1080/19490976.2022.2108279
Abstract: ABSTRACT The intestinal microbiota produces β-glucuronidase that plays an essential role in the metabolism of the immunosuppressant mycophenolate mofetil (MMF). This drug is commonly used in organ and hematopoietic cell transplantation (HCT), with variations in… read more here.
Keywords: glucuronidase activity; kidney; hematopoietic cell; activity differs ... See more keywords
Association of ß-glucuronidase activity with menopausal status, ethnicity, adiposity, and inflammation in women
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DOI: 10.1097/gme.0000000000002106
Abstract: β-Glucuronidase was positively associated with Hispanic ethnicity, C-reactive protein, body mass index and total fat mass, but not menopausal status nor lean mass, with future studies required to understand mechanistic underpinnings for these findings. Abstract… read more here.
Keywords: activity; menopausal status; glucuronidase; ethnicity ... See more keywords
Vancomycin relieves mycophenolate mofetil–induced gastrointestinal toxicity by eliminating gut bacterial β-glucuronidase activity
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DOI: 10.1126/sciadv.aax2358
Abstract: Toxicity from the immunosuppressant mycophenolate mofetil is prevented by eliminating gut bacteria expressing β-glucuronidase. Mycophenolate mofetil (MMF) is commonly prescribed and has proven advantages over other immunosuppressive drugs. However, frequent gastrointestinal side effects through an… read more here.
Keywords: vancomycin relieves; eliminating gut; toxicity; glucuronidase ... See more keywords
Abstract 3319: Breath-based detection of lung cancer using exogenous volatile organic compound targeting β-glucuronidase in the tumor microenvironment
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DOI: 10.1158/1538-7445.am2023-3319
Abstract: Introduction: Numerous studies have sought potential breath biomarkers for lung cancer and many have promising results but, to date, no validated biomarkers with clear connections to cancer metabolism have been discovered. We aim to show… read more here.
Keywords: lung cancer; exogenous volatile; breath; lung ... See more keywords
Abstract 3002: Bone-protective curcumin circulates as a pro-drug conjugate that is activated in bone by β-glucuronidase
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DOI: 10.1158/1538-7445.sabcs18-3002
Abstract: Curcumin (CURC), a turmeric-derived dietary polyphenol, prevents osteoclast formation and bone resorption in murine models of arthritis, post-menopausal osteoporosis, and bone metastatic breast cancer despite being rapidly conjugated upon ingestion in both rodents and humans… read more here.
Keywords: curcumin; curc; cancer; pro drug ... See more keywords