Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception
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DOI: 10.1021/acscentsci.8b00239
Abstract: Microbial β-glucuronidases (GUSs) cause severe gut toxicities that limit the efficacy of cancer drugs and other therapeutics. Selective inhibitors of bacterial GUS have been shown to alleviate these side effects. Using structural and chemical biology,… read more here.
Keywords: via catalytic; inhibition; glucuronidase inhibition; microbial glucuronidase ... See more keywords