Rational Design, Synthesis, In Vitro, and In Silico Studies of Dihydropyrimidinone Derivatives as β-Glucuronidase Inhibitors
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DOI: 10.1155/2021/6664756
Abstract: In the current study, a series of dihydropyrimidinone derivatives were rationally designed as β-glucuronidase inhibitors. These designed compounds were successfully synthesized and characterized through various spectroscopic techniques such as IR, 1H-NMR, 13C-NMR, and EI-MS. A… read more here.
Keywords: design synthesis; glucuronidase inhibitors; rational design; vitro silico ... See more keywords
Chemical Constituent of β-Glucuronidase Inhibitors from the Root of Neolitsea acuminatissima
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DOI: 10.3390/molecules25215170
Abstract: Neolitsea acuminatissima (Lauraceae) is an endemic plant in Taiwan. One new carboline alkaloid, demethoxydaibucarboline A (1), two new eudesmanolide-type sesquiterpenes, methyl-neolitacumone A (2), neolitacumone E (3), and twelve known compounds (4–15) were isolated from the… read more here.
Keywords: root neolitsea; glucuronidase inhibitors; chemical constituent; constituent glucuronidase ... See more keywords
Synthesis of 2-Aminopyrimidine Derivatives and Their Evaluation as β-Glucuronidase Inhibitors: In Vitro and In Silico Studies
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DOI: 10.3390/molecules27227786
Abstract: Currently the discovery and development of potent β-glucuronidase inhibitors is an active area of research due to the observation that increased activity of this enzyme is associated with many pathological conditions, such as colon cancer,… read more here.
Keywords: aminopyrimidine derivatives; derivatives evaluation; glucuronidase inhibitors; evaluation glucuronidase ... See more keywords