Development and validation of an LC-MS/MS method for the quantification of flavonoid glucuronides (wogonoside, baicalin, and apigenin-glucuronide) in the bile and blood samples: application to a portal vein infusion study.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2020.113723
Abstract: Glucuronidation is one of the major metabolic pathways for flavonoids. However, quantification of flavonoid glucuronides in biological samples, especially in the bile, is sometimes challenging due to signal suppression by bile acids. The purpose of… read more here.
Keywords: flavonoid glucuronides; method; blood; glucuronide ... See more keywords
Distribution and fate of pharmaceuticals and their metabolite conjugates in a municipal wastewater treatment plant.
Sign Up to like & getrecommendations! Published in 2018 at "Water research"
DOI: 10.1016/j.watres.2018.08.034
Abstract: Some pharmaceutical conjugates can be excreted into wastewaters at levels rivalling those of the parent compounds; however, little is known about this potential reservoir of pharmaceuticals to aquatic systems. We evaluated the occurrence and distribution… read more here.
Keywords: thyroxine glucuronide; wastewater treatment; thyroxine; glucuronide ... See more keywords
Post-Deconvolution MS/MS Spectra Extraction with Data-Independent Acquisition for Comprehensive Profiling of Urinary Glucuronide-Conjugated Metabolome.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c03557
Abstract: Conjugation reactions are of critical significance in human metabolism. Identification of these conjugated metabolites is still challenging. Here, we propose a strategy, post-deconvolution MS/MS spectra extraction with data-independent acquisition (PDMS2E-DIA), to comprehensively profile the glucuronide-conjugated… read more here.
Keywords: spectra extraction; extraction data; post deconvolution; deconvolution spectra ... See more keywords
Oxyresveratrol and Gnetol Glucuronide Metabolites: Chemical Production, Structural Identification, Metabolism by Human and Rat Liver Fractions, and In Vitro Anti-inflammatory Properties
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Agricultural and Food Chemistry"
DOI: 10.1021/acs.jafc.1c07831
Abstract: Stilbene metabolites are attracting great interest because many of them exhibit similar or even stronger biological effects than their parent compounds. Furthermore, the metabolized forms are predominant in biological fluids; therefore, their study is highly… read more here.
Keywords: human rat; glucuronide metabolites; orv glucuronide; production ... See more keywords
Separation of Isomeric Forms of Urolithin Glucuronides Using Supercritical Fluid Chromatography
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Agricultural and Food Chemistry"
DOI: 10.1021/acs.jafc.2c07145
Abstract: Urolithins are gut microbiota metabolites produced in humans after consuming foods containing ellagitannins and ellagic acid. Three urolithin metabotypes have been reported for different individuals depending on the final urolithins produced. After absorption, they are… read more here.
Keywords: urolithin glucuronides; using supercritical; supercritical fluid; glucuronide ... See more keywords
Comparative Analysis of ELISA Immunoassay and LC-QTOF For Opiate Screening.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of analytical toxicology"
DOI: 10.1093/jat/bkz109
Abstract: A comparative analysis of enzyme-linked immunosorbent assay (ELISA) and quadropole time-of-flight mass spectrometry (LC-QTOF) for the detection of opioids in blood samples is presented. The Orange County Crime Lab (OCCL) was concerned that the opioid… read more here.
Keywords: comparative analysis; analysis elisa; analysis; elisa immunoassay ... See more keywords
Effect of Valproic Acid on the Metabolic Spectrum of Clozapine in Patients With Schizophrenia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Psychopharmacology"
DOI: 10.1097/jcp.0000000000001507
Abstract: Abstract Background Valproic acid (VPA) is frequently used with clozapine (CLZ) as mood stabilizer and/or seizure prophylaxis. Valproic acid is known to reduce N-desmethylclozapine (N-DMC) but not CLZ levels. This leads to the hypothesis that… read more here.
Keywords: effect; clz; glucuronide; clozapine ... See more keywords
Gas-Phase Rearrangement of the O-Glucuronide of Vildagliptin Forms Product-Ion Fragments Suggesting Wrongly an N-Glucuronide
Sign Up to like & getrecommendations! Published in 2018 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.118.085597
Abstract: The O-glucuronide of vildagliptin, a dipeptidyl peptidase 4 inhibitor, is a major metabolite in monkeys and a minor metabolite in humans, rats, and dogs. Its product ion spectrum shows fragments that can be explained only… read more here.
Keywords: phase rearrangement; gas; ion; glucuronide ... See more keywords
In Vitro Evidence of Potential Interactions between CYP2C8 and Candesartan Acyl-β-D-glucuronide in the Liver
Sign Up to like & getrecommendations! Published in 2021 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.120.000126
Abstract: Growing evidence suggests that certain glucuronides function as potent inhibitors of CYP2C8. We previously reported the possibility of drug-drug interactions between candesartan cilexetil and paclitaxel. In this study, we evaluated the effects of candesartan N2-glucuronide… read more here.
Keywords: candesartan acyl; candesartan; acyl glucuronide; drug ... See more keywords
Determination of Acyl-, O-, and N-Glucuronide Using Chemical Derivatization Coupled with Liquid Chromatography–High-Resolution Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.122.000832
Abstract: Glucuronidation is the most common phase II metabolic pathway to eliminate small molecule drugs from the body. However, determination of glucuronide structure is quite challenging by mass spectrometry due to its inability to generate structure-informative… read more here.
Keywords: mass spectrometry; acyl glucuronides; glucuronide;
Characterization of Clofazimine Metabolism in Human Liver Microsomal Incubation In Vitro
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00565-22
Abstract: Clofazimine [N,5-bis(4-chlorophenyl)-3-[(propane-2-yl)rimino]-3,5-dihydrophenazin-2-amine] is an antimycobacterial agent used as a second-line antituberculosis (anti-TB) drug. Nonetheless, little information is known about the metabolic routes of clofazimine, and the enzymes involved in metabolism. ABSTRACT Clofazimine [N,5-bis(4-chlorophenyl)-3-[(propane-2-yl)rimino]-3,5-dihydrophenazin-2-amine] is an… read more here.
Keywords: clofazimine; metabolism; oxidative metabolites; human liver ... See more keywords