Glutamate delta 1 receptor regulates autophagy mechanisms and affects excitatory synapse maturation in the somatosensory cortex.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacological research"
DOI: 10.1016/j.phrs.2022.106144
Abstract: The glutamate delta family of receptors is composed of GluD1 and GluD2 and serve as synaptic organizers. We have previously demonstrated several autism-like molecular and behavioral phenotypes including an increase in dendritic spines in GluD1… read more here.
Keywords: autophagy mechanisms; somatosensory cortex; glud1; glutamate delta ... See more keywords
Glutamate delta-1 receptor regulates cocaine-induced plasticity in the nucleus accumbens
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DOI: 10.1038/s41398-018-0273-9
Abstract: Cocaine exposure induces plasticity of glutamatergic synapses of medium spiny neurons (MSNs) in the nucleus accumbens (NAc), which has been proposed to contribute to its addictive behavior. The mechanisms underlying cocaine-induced plasticity are not fully… read more here.
Keywords: cocaine induced; cocaine; glud1; receptor ... See more keywords
Mosaic GLUD1 Mutations Associated with Hyperinsulinism Hyperammonemia Syndrome
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DOI: 10.1159/000526203
Abstract: Introduction: The hyperinsulinemia-hyperammonemia syndrome (HIHA) is the second most common cause of congenital hyperinsulinism and is caused by activating heterozygous missense mutations in GLUD1. In the majority of HIHA cases, the GLUD1 mutation is found… read more here.
Keywords: glud1 mutations; mosaic glud1; glud1; peripheral blood ... See more keywords
GLUD1 suppresses renal tumorigenesis and development via inhibiting PI3K/Akt/mTOR pathway
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DOI: 10.3389/fonc.2022.975517
Abstract: Growing cancer cells are addicted to glutamine. Glutamate dehydrogenase 1 (GLUD1) is one of key enzymes in glutamine metabolism and plays a critical role in the malignancy of diverse tumors. However, its role and molecular… read more here.
Keywords: inhibiting pi3k; pi3k akt; ccrcc; glud1 level ... See more keywords