Mitochondrial enzyme GLUD2 plays a critical role in glioblastoma progression
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DOI: 10.1016/j.ebiom.2018.10.008
Abstract: Background Glioblastoma (GBM) is the most frequent and malignant primary brain tumor in adults and despite the progress in surgical procedures and therapy options, the overall survival remains very poor. Glutamate and α-KG are fundamental… read more here.
Keywords: glioblastoma; glud2; gbm; proliferation ... See more keywords
mGlu1 receptor canonical signaling pathway contributes to the opening of the orphan GluD2 receptor
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2016.06.001
Abstract: &NA; The orphan Glutamate receptor Delta2 (GluD2) intrinsic ion channel activity is indirectly triggered by glutamate through stimulation of the metabotropic glutamate receptor 1 (mGlu1), in cerebellar Purkinje cells. However, the mechanisms of GluD2 ion… read more here.
Keywords: mglu1; canonical signaling; glud2; glud2 channels ... See more keywords