Haven't got a glue: Protein surface variation for the design of molecular glue degraders.
Sign Up to like & getrecommendations! Published in 2021 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2021.04.009
Abstract: Molecular glue degraders are small, drug-like compounds that induce interactions between an E3 ubiquitin ligase and a target, which result in ubiquitination and subsequent degradation of the recruited protein. In recent years, serendipitous discoveries revealed… read more here.
Keywords: molecular glue; glue degraders; protein surface;
Abstract 3424: Template-assisted covalent modification of DCAF16 enables BRD4 molecular glue degraders
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3424
Abstract: Molecular glue degraders have emerged as a powerful class of small-molecule therapeutics, as demonstrated by the clinical successes of thalidomide analogs in the treatment of hematological malignancies. These small molecules act by recruiting ubiquitin ligases… read more here.
Keywords: dcaf16; glue degraders; covalent modification; molecular glue ... See more keywords