Assembly and Trafficking of Homomeric and Heteromeric Kainate Receptors with Impaired Ligand Binding Sites
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DOI: 10.1007/s11064-018-2654-0
Abstract: Kainate receptors (KARs) are a subfamily of ionotropic glutamate receptors (iGluRs) mediating excitatory synaptic transmission. Cell surface expressed KARs modulate the excitability of neuronal networks. The transfer of iGluRs from the endoplasmic reticulum (ER) to… read more here.
Keywords: surface; ligand binding; binding sites; kainate receptors ... See more keywords
The role of S‐nitrosylation of kainate‐type of ionotropic glutamate receptor 2 in epilepsy induced by kainic acid
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DOI: 10.1111/jnc.14266
Abstract: Epilepsy is a chronic brain disease affecting millions of individuals. Kainate receptors, especially kainate‐type of ionotropic glutamate receptor 2 (GluK2), play an important role in epileptogenesis. Recent data showed that GluK2 could undergo post‐translational modifications… read more here.
Keywords: epilepsy; role; gluk2; sno gluk2 ... See more keywords
Structural Arrangement Produced by Concanavalin A Binding to Homomeric GluK2 Receptors
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DOI: 10.3390/membranes11080613
Abstract: Kainate receptors are members of the ionotropic glutamate receptor family. They form cation-specific transmembrane channels upon binding glutamate that desensitize in the continued presence of agonists. Concanavalin A (Con-A), a lectin, stabilizes the active open-channel… read more here.
Keywords: dimer interface; kainate receptor; gluk2; receptor ... See more keywords