Spinophilin‐dependent regulation of GluN2B‐containing NMDAR‐dependent calcium influx, GluN2B surface expression, and cleaved caspase expression
Sign Up to like & getrecommendations! Published in 2023 at "Synapse"
DOI: 10.1002/syn.22264
Abstract: N‐methyl‐d‐aspartate receptors (NMDARs) are calcium‐permeable ion channels that are ubiquitously expressed within the glutamatergic postsynaptic density. Phosphorylation of NMDAR subunits defines receptor conductance and surface localization, two alterations that can modulate overall channel activity. Modulation… read more here.
Keywords: spinophilin; calcium; glun2b containing; expression ... See more keywords
Blockade of GluN2B‐containing NMDA receptors reduces short‐term brain damage induced by early‐life status epilepticus
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2019.01.002
Abstract: HighlightsGluN2B‐containing NMDAR blockage did not terminate status epilepticus.Ketamine and CI‐1041 treatments accelerated weight recovery after status epilepticus.Status epilepticus termination is not required for prevention of neuronal loss.GluN2B‐containing NMDAR are involved in status epilepticus‐induced brain damage.CP‐101,606… read more here.
Keywords: status epilepticus; glun2b containing; containing nmdar;
Prolonged ketamine exposure induces increased activity of the GluN2B-containing N-methyl-d-aspartate receptor in the anterior cingulate cortex of neonatal rats.
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicology and teratology"
DOI: 10.1016/j.ntt.2017.07.005
Abstract: Ketamine is a commonly used anesthetic among pediatric patients due to its high efficacy. However, it has been demonstrated by several preclinical studies that, widespread accelerated programmed death of neurons (neuroapoptosis) occurs due to prolonged… read more here.
Keywords: methyl aspartate; ketamine; exposure; glun2b containing ... See more keywords