High density lipoprotein (HDL) reverses palmitic acid induced energy metabolism imbalance by switching CD36 and GLUT4 signaling pathways in cardiomyocyte
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26007
Abstract: In our previous study palmitic acid (PA) induced lipotoxicity and switches energy metabolism from CD36 to GLUT4 in H9c2 cells. Low level of high density lipoprotein (HDL) is an independent risk factor for cardiac hypertrophy.… read more here.
Keywords: pathway proteins; acid induced; hdl; cd36 glut4 ... See more keywords
Insulin modulates hippocampally-mediated spatial working memory via glucose transporter-4
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.09.033
Abstract: &NA; The insulin‐regulated glucose transporter, GluT4, is a key molecule in peripheral insulin signaling. Although GluT4 is abundantly expressed in neurons of specific brain regions such as the hippocampus, the functional role of neuronal GluT4… read more here.
Keywords: insulin; glucose transporter; mediated spatial; hippocampally mediated ... See more keywords
Molecular Basis of GLUT4 in Glucose Transport: Atomistic Molecular Dynamics Study
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.768
Abstract: The glucose transporter 4 (GLUT4) is one of the most important glucose transporter proteins for the absorption of glucose from the plasma circulation after a meal or during exercise. It is present in skeletal muscle,… read more here.
Keywords: molecular dynamics; glucose transporter; atomistic molecular; glucose transport ... See more keywords
MicroRNA‐17 impairs glucose metabolism in insulin‐resistant skeletal muscle via repressing glucose transporter 4 expression
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.08.036
Abstract: Abstract Elimination of glucose transporter 4 (GLUT4) inevitably induces insulin resistance (IR), aggravating inflammation‐ and oxidative stress‐related disorders. However, the underlying molecular mechanisms remain incompletely understood. In this study, we identified miR‐17 as an important… read more here.
Keywords: glucose transporter; mir; glucose metabolism; expression ... See more keywords
Prior exercise in humans redistributes intramuscular GLUT4 and enhances insulin-stimulated sarcolemmal and endosomal GLUT4 translocation
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2020.100998
Abstract: Objective Exercise is a cornerstone in the management of skeletal muscle insulin-resistance. A well-established benefit of a single bout of exercise is increased insulin sensitivity for hours post-exercise in the previously exercised musculature. Although rodent… read more here.
Keywords: insulin; translocation; prior exercise; insulin stimulated ... See more keywords
The deubiquitinating enzyme USP25 binds tankyrase and regulates trafficking of the facilitative glucose transporter GLUT4 in adipocytes
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-40596-5
Abstract: Key to whole body glucose homeostasis is the ability of fat and muscle cells to sequester the facilitative glucose transporter GLUT4 in an intracellular compartment from where it can be mobilized in response to insulin.… read more here.
Keywords: insulin; glucose transporter; enzyme usp25; glut4 ... See more keywords
Forkhead box C2 is associated with insulin resistance in gestational diabetes mellitus
Sign Up to like & getrecommendations! Published in 2022 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2022.2072485
Abstract: Abstract Objective This study aimed to investigate serum levels of adiponectin, and the mRNA expression of forkhead box C2 (FOXC2) and glucose transporter-4 (GLUT4) in visceral adipose tissue obtained from patients with gestational diabetes mellitus… read more here.
Keywords: forkhead box; gestational diabetes; diabetes mellitus; visceral adipose ... See more keywords
Altered Central Nutrient Sensing in Male Mice Lacking Insulin Receptors in Glut4-expressing Neurons.
Sign Up to like & getrecommendations! Published in 2019 at "Endocrinology"
DOI: 10.1210/en.2019-00341
Abstract: Insulin signaling in the central nervous system influences satiety, counterregulation, and peripheral insulin sensitivity. Neurons expressing the Glut4 glucose transporter influence peripheral insulin sensitivity. Here, we analyzed the effects of insulin receptor (IR) signaling in… read more here.
Keywords: insulin; response; glut4 neurons; glut4 expressing ... See more keywords
Myostatin inhibits glucose uptake via suppression of insulin‐dependent and ‐independent signaling pathways in myoblasts
Sign Up to like & getrecommendations! Published in 2018 at "Physiological Reports"
DOI: 10.14814/phy2.13837
Abstract: The glucose transporter 4 (Glut4) mediates insulin‐dependent glucose uptake. Glut4 expression levels are correlated with whole‐body glucose homeostasis. Insulin signaling is known to recruit Glut4 to the cell surface. Expression of Glut4 is subject to… read more here.
Keywords: insulin; insulin dependent; mstn; glucose uptake ... See more keywords
296-OR: Identification and Characterization of New Players in Insulin-Controlled GLUT4 Trafficking
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes"
DOI: 10.2337/db20-296-or
Abstract: The anabolic hormone insulin promotes glucose uptake by triggering the translocation of the glucose transporter GLUT4 from intracellular storage vesicles to the cell surface through exocytosis. Upon the termination of insulin signaling, GLUT4 gradually returns… read more here.
Keywords: insulin; glut4 trafficking; osbpl8 osbpl10; endocytosis ... See more keywords
Adipose Tissue, Inter-Organ Communication, and the Path to Type 2 Diabetes: The 2016 Banting Medal for Scientific Achievement Lecture
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes"
DOI: 10.2337/dbi18-0035
Abstract: My scientific career has focused on understanding the mechanisms underlying insulin resistance with the goal of developing new strategies to prevent and treat type 2 diabetes. My early studies focused on understanding how insulin promotes… read more here.
Keywords: insulin; tissue; type diabetes; adipose tissue ... See more keywords