Electrical pulse stimulation induces GLUT4 translocation in a Rac‐Akt‐dependent manner in C2C12 myotubes
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.12982
Abstract: Muscle contraction increases skeletal muscle glucose uptake, but the underlying mechanisms are not fully elucidated. While important for insulin‐stimulated glucose uptake, the role of Akt in contraction‐stimulated muscle glucose uptake is controversial. In our study,… read more here.
Keywords: electrical pulse; pulse stimulation; glut4 translocation; translocation ... See more keywords
The livestock growth-promoter zeranol facilitates GLUT4 translocation in 3T3 L1 adipocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2020.126772
Abstract: Zeranol is an approved but controversial growth-promoting agent for livestock in North America. It is a mycotoxin metabolite secreted by the Fusarium family fungi. The regulatory bodies in this region have established the acceptable daily… read more here.
Keywords: glut4 translocation; growth promoting; 3t3 adipocytes; translocation ... See more keywords
Oleanolic acid induces a dual agonist action on PPARγ/α and GLUT4 translocation: A pentacyclic triterpene for dyslipidemia and type 2 diabetes.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173252
Abstract: Type 2 diabetes (T2D) is a metabolic disease characterized by defects in glycemia regulation. This disease is associated with alterations in insulin action and lipid metabolism, generating hyperglycemia and dyslipidemias. Currently, it is necessary to… read more here.
Keywords: ppar; glut4 translocation; type diabetes; oleanolic acid ... See more keywords
A Citrullus colocynthis fruit extract acutely enhances insulin-induced GLUT4 translocation and glucose uptake in adipocytes by increasing PKB phosphorylation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113772
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Citrullus colocynthis (L.) Schrad is a common fruit in traditional medicine and used as remedy against various diseases, especially diabetes. Up to now, its anti-diabetic effects have been fully attributed to its enhancement… read more here.
Keywords: insulin; glut4 translocation; fruit; glucose uptake ... See more keywords
Novel dual-color drug screening model for GLUT4 translocation in adipocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and cellular probes"
DOI: 10.1016/j.mcp.2019.01.002
Abstract: Insulin-responsive glucose transporter type 4 (GLUT4) translocation plays a major role in controlling glucose uptake in adipose tissue and muscle, maintaining homeostasis and preventing hyperglycemia. Screening for chemicals enhancing GLUT4 translocation is an approach for… read more here.
Keywords: drug; dual color; translocation; glut4 translocation ... See more keywords
Synthesis of novel glycosyl-1,2,3-1H-triazolyl methyl quinazolin-4(3H)-ones and their effect on GLUT4 translocation
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2016.11.074
Abstract: Cu(OTf)2 catalyzed synthesis of propargylated 2,3-dihydroquinazolin-4(1H)-ones has been accomplished from 2-amino-N-propargyl benzamides and aromatic aldehydes under MW irradiation. Next, a series of novel glycosyl triazolyl methyl quinazolin-4(3H)-ones have been synthesized by CuAAC reaction of propargylated… read more here.
Keywords: novel glycosyl; glut4 translocation; triazolyl methyl; quinazolin ones ... See more keywords
Effects of DEHP and its metabolite MEHP on insulin signalling and proteins involved in GLUT4 translocation in cultured L6 myotubes.
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology"
DOI: 10.1016/j.tox.2017.05.005
Abstract: Di-(2-ethyl hexyl) phthalate (DEHP) is the plasticizer used in variety of medical and consumer products to impart structural flexibility. DEHP and its primary metabolite mono-(2-ethyl hexyl)phthalate (MEHP) posed a considerable interest because of their contribution… read more here.
Keywords: insulin; effects dehp; mehp insulin; glut4 translocation ... See more keywords
Mitofusion is required for MOTS‐c induced GLUT4 translocation
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-93735-2
Abstract: MOTS‐c (mitochondrial ORF of the twelve S-c) is a 16-amino-acid mitochondrial peptide that has been shown to counter insulin resistance and alleviate obesity in vivo. However, the mechanisms involved in the pharmacological action of MOTS-c… read more here.
Keywords: glut4 translocation; mitofusion required; mots induced; mitofusion ... See more keywords
Fluorescence microscopy-based quantitation of GLUT4 translocation
Sign Up to like & getrecommendations! Published in 2022 at "Methods and Applications in Fluorescence"
DOI: 10.1088/2050-6120/ac4998
Abstract: Postprandial insulin-stimulated glucose uptake into target tissue is crucial for the maintenance of normal blood glucose homeostasis. This step is rate-limited by the number of facilitative glucose transporters type 4 (GLUT4) present in the plasma… read more here.
Keywords: translocation; microscopy based; microscopy; glut4 translocation ... See more keywords
A Novel Partial PPARγ Agonist Has Weaker Lipogenic Effect in Adipocytes and Stimulates GLUT4 Translocation in Skeletal Muscle Cells via AMPK-Dependent Signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacology"
DOI: 10.1159/000519331
Abstract: INTRODUCTION Peroxisome proliferator-activated receptor gamma (PPARγ) agonists are highly effective in treating insulin resistance. However, associated side effects such as weight gain due to increase in adipogenesis and lipogenesis hinder their clinical use. The aim… read more here.
Keywords: ppar; glut4 translocation; novel partial; effect ... See more keywords
Neuregulin-1β increases glucose uptake and promotes GLUT4 translocation in palmitate-treated C2C12 myotubes by activating PI3K/AKT signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1066279
Abstract: Insulin resistance (IR) is a feature of type 2 diabetes (T2DM) accompanied by reduced glucose uptake and glucose transporter 4 (GLUT4) translocation by skeletal muscle. Neuregulin-1β (NRG-1β) is essential for myogenesis and the regulation of… read more here.
Keywords: translocation; akt signaling; c2c12 myotubes; glut4 translocation ... See more keywords