Reduced uptake of [11C]‐ABP688, a PET tracer for metabolic glutamate receptor 5 in hippocampus and amygdala in Alzheimer’s dementia
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DOI: 10.1002/brb3.1632
Abstract: Metabotropic glutamate receptors play a critical role in the pathogenesis of Alzheimer's disease due to their involvement in processes of memory formation, neuroplasticity, and synaptotoxity. The objective of the current study was to study mGluR5… read more here.
Keywords: reduced uptake; glutamate; alzheimer dementia; 11c abp688 ... See more keywords
Assessing differential effects of single and accelerated low‐frequency rTMS to the visual cortex on GABA and glutamate concentrations
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DOI: 10.1002/brb3.1845
Abstract: The application of repetitive transcranial magnetic stimulation (rTMS) for therapeutic use in visual‐related disorders and its underlying mechanisms in the visual cortex is under‐investigated. Additionally, there is little examination of rTMS adverse effects particularly with… read more here.
Keywords: assessing differential; rtms; gaba; glutamate ... See more keywords
The role of hippocampal glial glutamate transporter (GLT‐1) in morphine‐induced behavioral responses
Sign Up to like & getrecommendations! Published in 2021 at "Brain and Behavior"
DOI: 10.1002/brb3.2323
Abstract: Opioid abuse modifies synaptic plasticity, which leads to behavioral changes, such as morphine dependence, but the mechanism remains poorly understood. Glial cells play an important role in the modulation of synaptic plasticity and are involved… read more here.
Keywords: glt; morphine dependence; glutamate; role hippocampal ... See more keywords
The effect of glutamate on ghrelin release in mice
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DOI: 10.1002/cbin.10728
Abstract: Ghrelin is abundantly produced in the stomach. Here, we found that glutamate decreased ghrelin expression and release in ghrelin‐producing cells, and decreased levels of food intake and plasma acyl‐ghrelin in mice. Treatment with siRNA of… read more here.
Keywords: effect glutamate; mice; ghrelin release; glutamate ... See more keywords
Neurosteroid dehydroepiandrosterone enhances activity and trafficking of astrocytic GLT‐1 via σ1 receptor‐mediated PKC activation in the hippocampal dentate gyrus of rats
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23175
Abstract: Neurosteroid dehydroepiandrosterone (DHEA) has been reported to exert a potent neuroprotective effect against glutamate‐induced excitotoxicity. However, the underlying mechanism remains to be elucidated. One of the possible mechanisms may be an involvement of astrocytic glutamate… read more here.
Keywords: glt; dentate gyrus; activity; neurosteroid dehydroepiandrosterone ... See more keywords
G protein‐coupled receptor 37‐like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23198
Abstract: We show that the G protein‐coupled receptor GPR37‐like 1 (GPR37L1) is expressed in most astrocytes and some oligodendrocyte precursors in the mouse central nervous system. This contrasts with GPR37, which is mainly in mature oligodendrocytes.… read more here.
Keywords: astrocyte glutamate; protein coupled; coupled receptor; glutamate transporters ... See more keywords
Constitutive downregulation protein kinase C epsilon in hSOD1G93A astrocytes influences mGluR5 signaling and the regulation of glutamate uptake
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DOI: 10.1002/glia.23279
Abstract: Accumulating evidence indicates that motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is a non‐cell‐autonomous process and that impaired glutamate clearance by astrocytes, leading to excitotoxicity, could participate in progression of the disease. In astrocytes… read more here.
Keywords: glutamate uptake; glutamate; mglur5 activation; regulation glutamate ... See more keywords
HIV‐induced neuroinflammation inhibits oligodendrocyte maturation via glutamate‐dependent activation of the PERK arm of the integrated stress response
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DOI: 10.1002/glia.24033
Abstract: Despite combined antiretroviral therapy (cART), HIV‐associated neurocognitive disorder (HAND) affects 30–50% of HIV‐positive patients. Importantly, persistent white matter pathologies, specifically corpus callosum thinning and disruption of white matter microstructures observed in patients with HAND despite… read more here.
Keywords: oligodendrocyte maturation; hiv; hiv mdms; activation ... See more keywords
Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity
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DOI: 10.1002/glia.24106
Abstract: Astroglial excitatory amino acid transporter 2 (EAAT2, GLT‐1, and SLC1A2) regulates the duration and extent of neuronal excitation by removing glutamate from the synaptic cleft. Hence, an impairment in EAAT2 function could lead to an… read more here.
Keywords: excitability; epileptic seizures; glutamate; recurrent ... See more keywords
The influence of season on glutamate and GABA levels in the healthy human brain investigated by magnetic resonance spectroscopy imaging
Sign Up to like & getrecommendations! Published in 2023 at "Human Brain Mapping"
DOI: 10.1002/hbm.26236
Abstract: Seasonal changes in neurotransmitter systems have been demonstrated in imaging studies and are especially noticeable in diseased states such as seasonal affective disorder (SAD). These modulatory neurotransmitters, such as serotonin, are influencing glutamatergic and GABAergic… read more here.
Keywords: magnetic resonance; glutamate; spectroscopy; brain ... See more keywords
Specificity of exogenous acetate and glutamate as astrocyte substrates examined in acute brain slices from female mice using methionine sulfoximine (MSO) to inhibit glutamine synthesis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24038
Abstract: Removal of endogenously released glutamate is mediated primarily by astrocytes and exogenous 13C‐labeled glutamate has been applied to study glutamate metabolism in astrocytes. Likewise, studies have clearly established the relevance of 13C‐labeled acetate as an… read more here.
Keywords: mso; astrocyte; acetate; acetate glutamate ... See more keywords