Genetic variation at the catalytic subunit of glutamate cysteine ligase contributes to the susceptibility to sporadic colorectal cancer: a pilot study.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology reports"
DOI: 10.1007/s11033-022-07406-0
Abstract: BACKGROUND Glutathione is a tripeptide detoxifying a variety of exogenous and endogenous free radicals and carcinogens, and a deficiency of glutathione is associated with an increased host susceptibility to oxidative stress, a pathological condition implicated… read more here.
Keywords: glutamate cysteine; gclc; cancer; catalytic subunit ... See more keywords
Low tumor glutathione level as a sensitivity marker for glutamate-cysteine ligase inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "Oncology letters"
DOI: 10.3892/ol.2018.8447
Abstract: Previous metabolomic analyses of cancer have revealed elevated glutathione levels in tumors. An inhibitor of cystine uptake was identified to suppress glutathione biosynthesis, leading to ferroptosis, a novel iron-dependent form of cell death that differs… read more here.
Keywords: glutathione levels; bso; sensitivity; ferroptosis ... See more keywords