Allosteric discrimination at the NADH/ADP regulatory site of glutamate dehydrogenase
Sign Up to like & getrecommendations! Published in 2019 at "Protein Science"
DOI: 10.1002/pro.3748
Abstract: Glutamate dehydrogenase (GDH) is a target for treating insulin‐related disorders, such as hyperinsulinism hyperammonemia syndrome. Modeling native ligand binding has shown promise in designing GDH inhibitors and activators. Our computational investigation of the nicotinamide adenine… read more here.
Keywords: binding; nadh adp; site; glutamate dehydrogenase ... See more keywords
Crystal structure of glutamate dehydrogenase 3 from Candida albicans.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.07.014
Abstract: Glutamate dehydrogenase 3 from Candida albicans (CaGdh3) catalyzes the reversible oxidative deamination of l-glutamate, playing an important role in the yeast-to-hyphal transition of C. albicans. Here we report the crystal structures of CaGdh3 and its… read more here.
Keywords: candida albicans; dehydrogenase candida; glutamate; glutamate dehydrogenase ... See more keywords
Administration of chitosan-tripolyphosphate-DNA nanoparticles to knockdown glutamate dehydrogenase expression impairs transdeamination and gluconeogenesis in the liver.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2018.09.002
Abstract: Glutamate dehydrogenase (GDH) plays a major role in amino acid catabolism. To increase the current knowledge of GDH function, we analysed the effect of GDH silencing on liver intermediary metabolism from gilthead sea bream (Sparus… read more here.
Keywords: dehydrogenase; gdh; chitosan tripolyphosphate; administration chitosan ... See more keywords
Glutamate dehydrogenase is essential in the acclimation of Virgilia divaricata, a legume indigenous to the nutrient-poor Mediterranean-type ecosystems of the Cape Fynbos.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of plant physiology"
DOI: 10.1016/j.jplph.2019.153053
Abstract: Glutamate dehydrogenase (NAD(H)- GDH, EC 1.4.1.2) is an important enzyme in nitrogen (N) metabolism. It serves as a link between C and N metabolism, in its role of assimilating ammonia into glutamine or deaminating glutamate… read more here.
Keywords: gdh; divaricata legume; virgilia divaricata; mediterranean type ... See more keywords
Glutamate dehydrogenase: a novel candidate to diagnose Plasmodium falciparum through rapid diagnostic test in blood specimen from fever patients
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-62850-x
Abstract: In recent years, Plasmodium falciparum histidine-rich protein 2 gene deletion has been reported in India. Such isolates are prone to selective transmission and thus form a challenge to case management. As most of the rapid… read more here.
Keywords: falciparum; plasmodium falciparum; blood; glutamate dehydrogenase ... See more keywords
A smartphone-based fiber-optic aptasensor for label-free detection of Plasmodium falciparum glutamate dehydrogenase
Sign Up to like & getrecommendations! Published in 2020 at "Analytical Methods"
DOI: 10.1039/c9ay02406a
Abstract: A novel smartphone-based, multi-channel, optic fiber platform for quantitative detection of Plasmodium falciparum glutamate dehydrogenase (PfGDH) has been explored in this study. A four-channel smartphone slip-on accessory was fabricated to couple one end of the… read more here.
Keywords: detection; smartphone; plasmodium falciparum; plasmodium ... See more keywords
Glutamate dehydrogenase 1: A novel metabolic target in inhibiting acute myeloid leukaemia progression.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of haematology"
DOI: 10.1111/bjh.18884
Abstract: Glutamine metabolic reprogramming in acute myeloid leukaemia (AML) cells contributes to the decreased sensitivity to antileukemic drugs. Leukaemic cells, but not their myeloid counterparts, largely depend on glutamine. Glutamate dehydrogenase 1 (GDH1) is a regulation… read more here.
Keywords: glutamate dehydrogenase; acute myeloid; myeloid leukaemia; glutamate ... See more keywords
Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aam9305
Abstract: Cancer cells put ammonia back to work Ammonia, often considered a metabolic waste product, can be recycled to build new amino acids. Rapidly proliferating cells produce extracellular nitrogen. Spinelli et al. used metabolic tracing of… read more here.
Keywords: nitrogen; amino acids; ammonia; breast cancer ... See more keywords
Influence of glutamate dehydrogenase activity on L-proline synthesis
Sign Up to like & getrecommendations! Published in 2017 at "Applied Biochemistry and Microbiology"
DOI: 10.1134/s0003683817050064
Abstract: The influence of glutamate dehydrogenase activity on the production of L-proline in the producer strain Brevibacterium flavum AP111 was studied. Transformants of the Brevibacterium flavum strain AP111 were obtained with the use of a recombinant… read more here.
Keywords: dehydrogenase; influence glutamate; glutamate dehydrogenase; dehydrogenase activity ... See more keywords
Therapeutic targeting of glutamate dehydrogenase 1 that links metabolic reprogramming and Snail-mediated epithelial-mesenchymal transition in drug-resistant lung cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacological research"
DOI: 10.2139/ssrn.4156412
Abstract: Acquired drug resistance and epithelial-mesenchymal transition (EMT) mediated metastasis are two highly interacting determinants for non-small-cell lung cancer (NSCLC) prognosis. This study investigated the common mechanisms of drug resistance and EMT from the perspective of… read more here.
Keywords: lung cancer; mesenchymal transition; metabolic reprogramming; epithelial mesenchymal ... See more keywords
A Sustainable Approach for Synthesizing (R)-4-Aminopentanoic Acid From Levulinic Acid Catalyzed by Structure-Guided Tailored Glutamate Dehydrogenase
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2021.770302
Abstract: In this study, a novel enzymatic approach to transform levulinic acid (LA), which can be obtained from biomass, into value-added (R)-4-aminopentanoic acid using an engineered glutamate dehydrogenase from Escherichia coli (EcGDH) was developed. Through crystal… read more here.
Keywords: aminopentanoic acid; acid; glutamate dehydrogenase; levulinic acid ... See more keywords