Erratum to: O-GlcNAc Glycosylation of nNOS Promotes Neuronal Apoptosis Following Glutamate Excitotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0495-z
Abstract: Ischemic stroke is a dominant health problem with extremely high rates of mortality and disability. The main mechanism of neuronal injury after stroke is excitotoxicity, during which the activation of neuronal nitric oxide synthase (nNOS)… read more here.
Keywords: glcnac; glcnacylation nnos; apoptosis; excitotoxicity ... See more keywords
Rutin improves glutamate uptake and inhibits glutamate excitotoxicity in rat brain slices
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biology Reports"
DOI: 10.1007/s11033-021-06145-y
Abstract: Rutin is an important flavonoid consumed in the daily diet. It is also known as vitamin P and has been extensively investigated due to its pharmacological properties. On the other hand, neuronal death induced by… read more here.
Keywords: glutamate uptake; brain; wistar rats; glutamate ... See more keywords
Viscoelasticity and Volume of Cortical Neurons under Glutamate Excitotoxicity and Osmotic Challenges.
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DOI: 10.1016/j.bpj.2020.09.022
Abstract: Neural activity depends on the maintenance of ionic and osmotic homeostasis. Under these conditions, the cell volume must be regulated to maintain optimal neural function. A disturbance in the neuronal volume regulation often occurs in… read more here.
Keywords: osmotic challenges; viscoelastic properties; glutamate excitotoxicity; cortical neurons ... See more keywords
Akt / GSK3β / Nrf2 / HO-1 pathway activation by flurbiprofen protects the hippocampal neurons in a rat model of glutamate excitotoxicity
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108654
Abstract: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates redox homeostasis of the cell through regulation of the antioxidant response element genes transcription. Nrf2 also regulates the antiapoptotic Bcl-2 gene. Nrf2… read more here.
Keywords: excitotoxicity; akt gsk3; pathway; glutamate ... See more keywords
Developmental exposure to glyphosate-based herbicide and depressive-like behavior in adult offspring: Implication of glutamate excitotoxicity and oxidative stress.
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology"
DOI: 10.1016/j.tox.2017.06.001
Abstract: We have previously demonstrated that maternal exposure to glyphosate-based herbicide (GBH) leads to glutamate excitotoxicity in 15-day-old rat hippocampus. The present study was conducted in order to investigate the effects of subchronic exposure to GBH… read more here.
Keywords: oxidative stress; adult; exposure; glutamate excitotoxicity ... See more keywords
Inhibition of Ferroptosis Attenuates Glutamate Excitotoxicity and Nuclear Autophagy in a CLP Septic Mouse Model
Sign Up to like & getrecommendations! Published in 2022 at "SHOCK"
DOI: 10.1097/shk.0000000000001893
Abstract: ABSTRACT Sepsis-associated encephalopathy (SAE) often manifests in severe diffuse cerebral dysfunction due to an aberrant systemic immune response to infection. The underlying pathophysiology of SAE is not entirely understood but is likely a multifactorial process… read more here.
Keywords: nuclear autophagy; inhibition ferroptosis; sae; glutamate excitotoxicity ... See more keywords
The small molecule inhibitor PR-619 protects retinal ganglion cells against glutamate excitotoxicity
Sign Up to like & getrecommendations! Published in 2020 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001522
Abstract: Glutamate excitotoxicity may contribute to the death of retinal ganglion cell (RGC) in glaucoma and other retinal diseases such as ischemia. Deubiquitinating enzyme (DUB) inhibitors are emerging as attractive targets for pharmacological intervention in neurodegenerative… read more here.
Keywords: glutamate excitotoxicity; excitotoxicity; rgcs; retinal ganglion ... See more keywords
Isoliquiritigenin Protects Neuronal Cells against Glutamate Excitotoxicity
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DOI: 10.3390/membranes12111052
Abstract: It is considered that glutamate excitotoxicity may be a major factor in the pathological death of neurons and mediate the development of neurodegenerative diseases in humans. Here, we show that isoliquiritigenin (ILG) at a concentration… read more here.
Keywords: protects neuronal; excitotoxicity; isoliquiritigenin protects; glutamate excitotoxicity ... See more keywords
Quercetin’s Effects on Glutamate Cytotoxicity
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DOI: 10.3390/molecules27217620
Abstract: The potentially therapeutic effects of the naturally abundant plant flavonoid quercetin have been extensively studied. An extensive body of literature suggests that quercetin’s powerful antioxidant effects may relate to its ability to treat disease. Glutamate… read more here.
Keywords: cell death; glutamate excitotoxicity; quercetin; glutamate ... See more keywords
Astrocytes enhance the tolerance of rat cortical neurons to glutamate excitotoxicity
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DOI: 10.3892/mmr.2018.9799
Abstract: Glutamate excitotoxicity is responsible for neuronal death in acute neurological disorders, including stroke, trauma and neurodegenerative diseases. Astrocytes are the main cells for the removal of glutamate in the synaptic cleft and may affect the… read more here.
Keywords: rat cortical; neurons glutamate; absence astrocytes; cortical neurons ... See more keywords