Distinct Signaling by Ventral Tegmental Area Glutamate, GABA, and Combinatorial Glutamate-GABA Neurons in Motivated Behavior
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108094
Abstract: SUMMARY Ventral tegmental area (VTA) neurons play roles in reward and aversion. We recently discovered that the VTA has neurons that co-transmit glutamate and GABA (glutamate-GABA co-transmitting neurons), transmit glutamate without GABA (glutamate-transmitting neurons), or… read more here.
Keywords: motivated behavior; transmitting neurons; ventral tegmental; gaba ... See more keywords
A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2018.11.007
Abstract: Mood disorders represent the largest cause of disability worldwide. The monoaminergic deficiency hypothesis, which has dominated the conceptual framework for researching the pathophysiology of mood disorders and the development of novel treatment strategies, cannot fully… read more here.
Keywords: new generation; mood disorders; mood; neurotransmitter systems ... See more keywords
Fentanyl and naloxone effects on glutamate and GABA release rates from anterior hypothalamus in freely moving rats.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2018.07.029
Abstract: Fentanyl, a μ-opioid receptor agonist, has been studied for its neuro/psycho-pharmacological effects since its first clinical use; however, its effect on the release rate of the Central Nervous System (CNS) neurotransmitters has not been yet… read more here.
Keywords: gaba release; release rates; anterior hypothalamus; glutamate gaba ... See more keywords
Co-packaging of opposing neurotransmitters in individual synaptic vesicles in the central nervous system
Sign Up to like & getrecommendations! Published in 2022 at "Neuron"
DOI: 10.1016/j.neuron.2022.01.007
Abstract: Many mammalian neurons release multiple neurotransmitters to activate diverse classes of postsynaptic ionotropic receptors. Entopeduncular nucleus somatostatin (EP Sst+) projection neurons to the lateral habenula (LHb) release both glutamate and GABA, but it is unclear… read more here.
Keywords: opposing neurotransmitters; synaptic vesicles; packaging opposing; neurotransmitters individual ... See more keywords
Uridine attenuates morphine-induced conditioned place preference and regulates glutamate/GABA levels in mPFC of mice
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2017.10.004
Abstract: Abstract Several lines of evidence suggest that uridine, as a neuromodulator, plays an important role in drug addiction. We previously found that uridine circumvents morphine‐induced behavioral sensitization by decreasing the extracellular dopamine levels in the… read more here.
Keywords: morphine induced; stress induced; stress; glutamate gaba ... See more keywords
Glutamate, GABA and presynaptic markers involved in neurotransmission are differently affected by age in distinct mouse brain regions.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00220
Abstract: Molecular synaptic aging perturbs neurotransmission and decreases the potential for neuroplasticity. The direction and degree of changes observed in aging are often region or cell specific, hampering the generalization of age-related effects. Using real-time PCR… read more here.
Keywords: presynaptic markers; age; neurotransmission; glutamate gaba ... See more keywords
O6.3. ASSOCIATIONS BETWEEN COGNITIVE FUNCTION AND CORTICAL LEVELS OF GLUTAMATE AND GABA IN ANTIPSYCHOTIC-NAïVE PATIENTS WITH SCHIZOPHRENIA OR PSYCHOSIS
Sign Up to like & getrecommendations! Published in 2020 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sbaa028.032
Abstract: Abstract Background Dysfunctional glutamatergic and gamma-aminobutyric acid (GABA)ergic neurotransmission may be part of the schizophrenia pathophysiology and underlie cognitive deficits. Abnormal levels of glutamate and GABA have been found in patients with first-episode psychosis or… read more here.
Keywords: antipsychotic patients; levels glutamate; healthy controls; glutamate gaba ... See more keywords
Anandamide Hydrolysis Inhibition Reverses the Long-Term Behavioral and Gene Expression Alterations Induced by MK-801 in Male Rats: Differential CB1 and CB2 Receptor-Mediated Effects.
Sign Up to like & getrecommendations! Published in 2022 at "Schizophrenia bulletin"
DOI: 10.1093/schbul/sbab153
Abstract: NMDA receptor blockade in rodents is commonly used to induce schizophrenia-like behavioral abnormalities, including cognitive deficits and social dysfunction. Aberrant glutamate and GABA transmission, particularly in adolescence, is implicated in these behavioral abnormalities. The endocannabinoid… read more here.
Keywords: cb2 receptor; cb1 cb2; expression; glutamate gaba ... See more keywords
The glutamate to γ-aminobutyric acid ratio in the posterior insula is associated with pain perception in healthy women but not in women with borderline personality disorder.
Sign Up to like & getrecommendations! Published in 2019 at "Pain"
DOI: 10.1097/j.pain.0000000000001641
Abstract: This study aimed to investigate whether the differences in pain perception between patients with borderline personality disorder (BPD) and healthy subjects (HCs) can be explained by differences in the glutamate/GABA ratio in the posterior insula.… read more here.
Keywords: ratio posterior; posterior insula; pain perception; glutamate gaba ... See more keywords
Two-color, one-photon uncaging of glutamate and GABA
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0187732
Abstract: Neuronal cells receive a variety of excitatory and inhibitory signals which they process to generate an output signal. In order to study the interaction between excitatory and inhibitory receptors with exogenously applied transmitters in the… read more here.
Keywords: uncaging glutamate; one photon; photon uncaging; two color ... See more keywords
Striatal Glutamate and GABA after High Frequency Subthalamic Stimulation in Parkinsonian Rat
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Korean Neurosurgical Society"
DOI: 10.3340/jkns.2016.0202.020
Abstract: Objective High frequency stimulation (HFS) of the subthalamic nucleus (STN) is recognized as an effective treatment of advanced Parkinson’s disease. However, the neurochemical basis of its effects remains unknown. The aim of this study is… read more here.
Keywords: stimulation; high frequency; group; glutamate gaba ... See more keywords