Restoring glutamate homeostasis in the nucleus accumbens via endocannabinoid-mimetic drug prevents relapse to cocaine seeking behavior in rats
Sign Up to like & getrecommendations! Published in 2021 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-021-00955-1
Abstract: Impaired glutamate homeostasis is a key characteristic of the neurobiology of drug addiction in rodent models and contributes to the vulnerability to relapse to drug seeking. Although disrupted astrocytic and presynaptic regulation of glutamate release… read more here.
Keywords: cocaine; glutamate homeostasis; glutamate; glutamate release ... See more keywords
The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05645-z
Abstract: Specialized glial subtypes provide support to developing and functioning neural networks. Astrocytes modulate information processing by neurotransmitter recycling and release of neuromodulatory substances, whereas ensheathing glial cells have not been associated with neuromodulatory functions yet.… read more here.
Keywords: neuronal activity; glutamate homeostasis; drosophila ensheathing; sulfite oxidase ... See more keywords
Activation of proline biosynthesis is critical to maintain glutamate homeostasis during acute methamphetamine exposure
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DOI: 10.1038/s41598-020-80917-7
Abstract: Methamphetamine (METH) is a highly addictive psychostimulant that causes long-lasting effects in the brain and increases the risk of developing neurodegenerative diseases. The cellular and molecular effects of METH in the brain are functionally linked… read more here.
Keywords: glutamate levels; meth exposure; glutamate homeostasis; exposure ... See more keywords
Impairment of glutamate homeostasis in the nucleus accumbens core underpins cross-sensitization to cocaine following chronic restraint stress
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.896268
Abstract: Though the facilitating influence of stress on drug abuse is well documented, the mechanisms underlying this interaction have yet to be fully elucidated. The present study explores the neurobiological mechanisms underpinning the sensitized response to… read more here.
Keywords: cocaine following; glutamate homeostasis; stress; glutamate ... See more keywords