Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity
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DOI: 10.1038/s41467-018-06512-7
Abstract: Selective disruption of synaptic drive to inhibitory neurons could contribute to the pathophysiology of various brain disorders. We have previously identified a GluN2A-selective positive allosteric modulator, GNE-8324, that selectively enhances N-methyl-d-aspartate receptor (NMDAR)-mediated synaptic responses… read more here.
Keywords: excitatory neurons; higher ambient; inhibitory; glutamate inhibitory ... See more keywords