Neuroanatomical changes in people with high schizotypy: relationship to glutamate levels
Sign Up to like & getrecommendations! Published in 2017 at "Psychological Medicine"
DOI: 10.1017/s0033291717003403
Abstract: Background Cortical glutamatergic dysfunction is thought to be fundamental for psychosis development, and may lead to structural degeneration through excitotoxicity. Glutamate levels have been related to gray matter volume (GMV) alterations in people at ultra-high… read more here.
Keywords: glutamate levels; high schizotypy; neuroanatomical changes; gmv ... See more keywords
Anterior cingulate glutamate levels associate with functional activation and connectivity during sensory integration in schizophrenia: a multimodal 1H-MRS and fMRI study.
Sign Up to like & getrecommendations! Published in 2022 at "Psychological medicine"
DOI: 10.1017/s0033291722001817
Abstract: BACKGROUND Glutamatergic dysfunction has been implicated in sensory integration deficits in schizophrenia, yet how glutamatergic function contributes to behavioural impairments and neural activities of sensory integration remains unknown. METHODS Fifty schizophrenia patients and 43 healthy… read more here.
Keywords: cingulate; glutamate levels; integration; sensory integration ... See more keywords
Changes in glutamate levels in anterior cingulate cortex following 16 weeks of antipsychotic treatment in antipsychotic-naïve first-episode psychosis patients
Sign Up to like & getrecommendations! Published in 2025 at "Psychological Medicine"
DOI: 10.1017/s0033291724003386
Abstract: Abstract Background Previous findings in psychosis have revealed mixed findings on glutamate (Glu) levels in the dorsal anterior cingulate cortex (dACC). Factors such as illness chronicity, methodology, and medication status have impeded a more nuanced… read more here.
Keywords: glutamate levels; glu levels; psychosis; glu ... See more keywords
Response to initial antipsychotic treatment in first episode psychosis is related to anterior cingulate glutamate levels: a multicentre 1H-MRS study (OPTiMiSE)
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/s41380-018-0082-9
Abstract: Conventional antipsychotic medication is ineffective in around a third of patients with schizophrenia, and the nature of the therapeutic response is unpredictable. We investigated whether response to antipsychotics is related to brain glutamate levels prior… read more here.
Keywords: glutamate levels; response; treatment; first episode ... See more keywords
Delta-9-tetrahydrocannabinol increases striatal glutamate levels in healthy individuals: implications for psychosis
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Psychiatry"
DOI: 10.1038/s41380-019-0374-8
Abstract: The neurobiological mechanisms underlying the association between cannabis use and acute or long-lasting psychosis are not completely understood. While some evidence suggests altered striatal dopamine may underlie the association, direct evidence that cannabis use affects… read more here.
Keywords: cannabis; glutamate levels; striatal glutamate; delta tetrahydrocannabinol ... See more keywords
A longitudinal study of hippocampal subfield volumes and hippocampal glutamate levels in antipsychotic-naïve first episode psychosis patients
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Psychiatry"
DOI: 10.1038/s41380-024-02812-1
Abstract: Previous studies have implicated hippocampal abnormalities in the neuropathology of psychosis spectrum disorders. Reduced hippocampal volume has been reported across all illness stages, and this atrophy has been hypothesized to be the result of glutamatergic… read more here.
Keywords: hippocampal glutamate; hippocampal subfield; subfield volumes; glutamate ... See more keywords
Cerebral glutamate levels over two years in initially antipsychotic-naïve first-episode patients with psychosis are related to clinical symptoms and cognition
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Psychiatry"
DOI: 10.1038/s41380-025-03234-3
Abstract: Although emerging evidence supports glutamatergic dysfunction in schizophrenia, clinical trials with glutamatergic compounds have overall been negative. This may be due to changes in glutamate levels during the course of illness. To address this, we… read more here.
Keywords: first episode; thalamic glutamate; two years; initially antipsychotic ... See more keywords
Anti-seizure effects of WS-3, a TRPM8 agonist, on focal onset seizure mouse model via reduction of extracellular glutamate levels
Sign Up to like & getrecommendations! Published in 2025 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-025-02143-x
Abstract: The development of novel anti-seizure drugs targeting novel mechanisms is crucial, especially for patients with intractable epilepsy. Previous studies using focal onset seizure rodent models have demonstrated that Icilin and WS-3, agonists of the transient… read more here.
Keywords: anti seizure; focal onset; seizure; onset seizure ... See more keywords
Glutamate levels in the anterior cingulate cortex in un-medicated first episode psychosis: a proton magnetic resonance spectroscopy study
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-45018-0
Abstract: Converging lines of evidence suggest that glutamatergic dysfunction may contribute to the pathophysiology of first episode psychosis. We investigated whether first episode psychosis patients free from all pharmacological treatments and illicit substances show cortical glutamatergic… read more here.
Keywords: glutamate levels; episode psychosis; first episode; spectroscopy ... See more keywords
Activation of proline biosynthesis is critical to maintain glutamate homeostasis during acute methamphetamine exposure
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-020-80917-7
Abstract: Methamphetamine (METH) is a highly addictive psychostimulant that causes long-lasting effects in the brain and increases the risk of developing neurodegenerative diseases. The cellular and molecular effects of METH in the brain are functionally linked… read more here.
Keywords: glutamate levels; meth exposure; glutamate homeostasis; exposure ... See more keywords
Relationship between symptom severity, glutamate levels, and N-methyl-D-aspartate receptor target microRNA expression in patients with panic disorder.
Sign Up to like & getrecommendations! Published in 2025 at "Psychiatric genetics"
DOI: 10.1097/ypg.0000000000000402
Abstract: BACKGROUND Glutamate, an excitatory neurotransmitter in the central nervous system, plays a role in neurodevelopment, learning, and memory. It is thought to interact with the GABAergic system in the development of panic symptoms; however, the… read more here.
Keywords: severity; panic disorder; expression; glutamate ... See more keywords