Neuroanatomical changes in people with high schizotypy: relationship to glutamate levels
Sign Up to like & getrecommendations! Published in 2017 at "Psychological Medicine"
DOI: 10.1017/s0033291717003403
Abstract: Background Cortical glutamatergic dysfunction is thought to be fundamental for psychosis development, and may lead to structural degeneration through excitotoxicity. Glutamate levels have been related to gray matter volume (GMV) alterations in people at ultra-high… read more here.
Keywords: glutamate levels; high schizotypy; neuroanatomical changes; gmv ... See more keywords
Anterior cingulate glutamate levels associate with functional activation and connectivity during sensory integration in schizophrenia: a multimodal 1H-MRS and fMRI study.
Sign Up to like & getrecommendations! Published in 2022 at "Psychological medicine"
DOI: 10.1017/s0033291722001817
Abstract: BACKGROUND Glutamatergic dysfunction has been implicated in sensory integration deficits in schizophrenia, yet how glutamatergic function contributes to behavioural impairments and neural activities of sensory integration remains unknown. METHODS Fifty schizophrenia patients and 43 healthy… read more here.
Keywords: cingulate; glutamate levels; integration; sensory integration ... See more keywords
Response to initial antipsychotic treatment in first episode psychosis is related to anterior cingulate glutamate levels: a multicentre 1H-MRS study (OPTiMiSE)
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/s41380-018-0082-9
Abstract: Conventional antipsychotic medication is ineffective in around a third of patients with schizophrenia, and the nature of the therapeutic response is unpredictable. We investigated whether response to antipsychotics is related to brain glutamate levels prior… read more here.
Keywords: glutamate levels; response; treatment; first episode ... See more keywords
Delta-9-tetrahydrocannabinol increases striatal glutamate levels in healthy individuals: implications for psychosis
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Psychiatry"
DOI: 10.1038/s41380-019-0374-8
Abstract: The neurobiological mechanisms underlying the association between cannabis use and acute or long-lasting psychosis are not completely understood. While some evidence suggests altered striatal dopamine may underlie the association, direct evidence that cannabis use affects… read more here.
Keywords: cannabis; glutamate levels; striatal glutamate; delta tetrahydrocannabinol ... See more keywords
Glutamate levels in the anterior cingulate cortex in un-medicated first episode psychosis: a proton magnetic resonance spectroscopy study
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-45018-0
Abstract: Converging lines of evidence suggest that glutamatergic dysfunction may contribute to the pathophysiology of first episode psychosis. We investigated whether first episode psychosis patients free from all pharmacological treatments and illicit substances show cortical glutamatergic… read more here.
Keywords: glutamate levels; episode psychosis; first episode; spectroscopy ... See more keywords
Activation of proline biosynthesis is critical to maintain glutamate homeostasis during acute methamphetamine exposure
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-020-80917-7
Abstract: Methamphetamine (METH) is a highly addictive psychostimulant that causes long-lasting effects in the brain and increases the risk of developing neurodegenerative diseases. The cellular and molecular effects of METH in the brain are functionally linked… read more here.
Keywords: glutamate levels; meth exposure; glutamate homeostasis; exposure ... See more keywords
Glutamate levels in the ventromedial prefrontal cortex and resting‐state functional connectivity within reward circuits in alcohol‐dependent patients
Sign Up to like & getrecommendations! Published in 2023 at "Addiction Biology"
DOI: 10.1111/adb.13272
Abstract: Great progress has been made in understanding the neural mechanisms associated with alcohol‐dependent (AD) patients. However, the interactions within the reward circuits of the patients need further exploration. Glutamatergic projections from the prefrontal cortex to… read more here.
Keywords: glutamate levels; functional connectivity; prefrontal cortex; within reward ... See more keywords
Repeated Administration of Cigarette Smoke Condensate Increases Glutamate Levels and Behavioral Sensitization
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2018.00047
Abstract: Nicotine, a nicotinic acetylcholine receptor agonist, produces the reinforcing effects of tobacco dependence by potentiating dopaminergic and glutamatergic neurotransmission. Non-nicotine alkaloids in tobacco also contribute to dependence by activating the cholinergic system. However, glutamatergic neurotransmission… read more here.
Keywords: glutamate levels; administration; administration cigarette; repeated administration ... See more keywords
Blood Glutamate Scavenging With Pyruvate as a Novel Preventative and Therapeutic Approach for Depressive-Like Behavior Following Traumatic Brain Injury in a Rat Model
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.832478
Abstract: Depression is a common and serious complication following traumatic brain injury (TBI). Both depression and TBI have independently been associated with pathologically elevated extracellular brain glutamate levels. In the setting of TBI, blood glutamate scavenging… read more here.
Keywords: pyruvate; glutamate; glutamate levels; brain ... See more keywords
Glutamate Levels and Resting Cerebral Blood Flow in Anterior Cingulate Cortex Are Associated at Rest and Immediately Following Infusion of S-Ketamine in Healthy Volunteers
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2018.00022
Abstract: Progressive loss of brain tissue is seen in some patients with schizophrenia and might be caused by increased levels of glutamate and resting cerebral blood flow (rCBF) alterations. Animal studies suggest that the normalisation of… read more here.
Keywords: glutamate levels; infusion ketamine; rcbf;