Human Metabotropic Glutamate Receptor 5 Antibodies Alter Receptor Levels and Behavior in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26362
Abstract: Ophelia syndrome or encephalitis with antibodies against the metabotropic glutamate receptor 5 (mGluR5) manifests with behavioral changes, memory deficits, and anxiety. To study the antibody pathogenicity, mice received continuous cerebroventricular infusion of patients' or controls'… read more here.
Keywords: receptor antibodies; human metabotropic; glutamate receptor; metabotropic glutamate ... See more keywords
ONIOM and FMO-EDA study of metabotropic glutamate receptor 1: Quantum insights into the allosteric binding site
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Quantum Chemistry"
DOI: 10.1002/qua.25617
Abstract: The crystal structure of metabotropic glutamate receptor 1 (mGluR1) complexed with 4-fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)thiazol-2-yl)-N-methylbenzamide (FITM, a negative allosteric modulator) and its twelve close structural analogs with a broad spectrum of affinities (2.4 nM 10 000 nM) were investigated… read more here.
Keywords: oniom fmo; fmo eda; metabotropic glutamate; glutamate receptor ... See more keywords
Metabolomics Analysis of Glutamate Receptor Function.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9077-1_11
Abstract: Metabolomics analysis provides a unique opportunity for comprehensive mapping of glutamatergic system function using high-throughput metabolite analysis and providing a perspective of the enzymatic activity, which cannot be obtained by other systems biology techniques. read more here.
Keywords: analysis; glutamate receptor; biology; analysis glutamate ... See more keywords
Glutamate Receptor Antibodies in Autoimmune Central Nervous System Disease: Basic Mechanisms, Clinical Features, and Antibody Detection.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9077-1_15
Abstract: Immune-mediated inflammation of the brain has been recognized for more than 50 years, although the initial descriptions were mainly thought to be secondary to an underlying neoplasm. Some of these paraneoplastic encephalitides express serum antibodies, but… read more here.
Keywords: antibodies autoimmune; glutamate receptor; encephalitis; biology ... See more keywords
A Bioluminescence Reporter Assay for Retinoic Acid Control of Translation of the GluR1 Subunit of the AMPA Glutamate Receptor
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-1571-9
Abstract: Retinoic acid (RA) regulates numerous aspects of central nervous system function through modulation of gene transcription via retinoic acid receptors (RARs). However, RA has important roles independent of gene transcription (non-genomic actions) and in the… read more here.
Keywords: rar; control; glutamate receptor; translation ... See more keywords
Dynamics of Glutamate Receptor Studied with Single Molecule FRET
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.104
Abstract: NMDA receptors are the main Ca2+ permeable excitatory receptors in the mammalian central nervous system. Glutamate along with glycine binding to the extracellular domain of the receptor leads to activation and upon prolonged exposure to… read more here.
Keywords: glutamate receptor; dynamics glutamate; extracellular domain; receptor ... See more keywords
Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons
Sign Up to like & getrecommendations! Published in 2019 at "Neuron"
DOI: 10.1016/j.neuron.2019.09.027
Abstract: Summary Fine orchestration of excitatory and inhibitory synaptic development is required for normal brain function, and alterations may cause neurodevelopmental disorders. Using sparse molecular manipulations in intact brain circuits, we show that the glutamate receptor… read more here.
Keywords: receptor delta; glutamate receptor; pyramidal neurons; cortical pyramidal ... See more keywords
Metabotropic glutamate receptor 5 neuroimaging in schizophrenia
Sign Up to like & getrecommendations! Published in 2017 at "Schizophrenia Research"
DOI: 10.1016/j.schres.2016.11.008
Abstract: The metabotropic glutamate receptor 5 (mGluR5) is a promising drug target for the treatment of schizophrenia. In this study, we compared mGluR5 distribution volume ration (DVR) in subjects with schizophrenia and healthy controls. Given our… read more here.
Keywords: metabotropic glutamate; schizophrenia; glutamate receptor;
Structure of the Arabidopsis Glutamate Receptor-like Channel GLR3.2 Ligand-Binding Domain.
Sign Up to like & getrecommendations! Published in 2020 at "Structure"
DOI: 10.1016/j.str.2020.09.006
Abstract: Glutamate receptor-like channels (GLRs) play important roles in numerous plant physiological processes. GLRs are homologous to ionotropic glutamate receptors (iGluRs) that mediate neurotransmission in vertebrates. Here we determine crystal structures of Arabidopsis thaliana GLR3.2 ligand-binding… read more here.
Keywords: glr3 ligand; glutamate receptor; ligand binding; receptor like ... See more keywords
Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.2c00234
Abstract: Recently determined structures of class C G protein-coupled receptors (GPCRs) revealed the location of allosteric binding sites and opened new opportunities for the discovery of novel modulators. In this work, molecular docking screens for allosteric… read more here.
Keywords: lead like; glutamate receptor; metabotropic glutamate; allosteric modulators ... See more keywords
Effects of Glutamate Receptor Activation on Local Oxygen Changes
Sign Up to like & getrecommendations! Published in 2017 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.7b00088
Abstract: Glutamate is ubiquitous throughout the brain and serves as the primary excitatory neurotransmitter. Neurons require energy to fire, and energetic substrates (i.e., O2, glucose) are renewed via cerebral blood flow (CBF) to maintain metabolic homeostasis.… read more here.
Keywords: receptor activation; activation local; glutamate receptor; effects glutamate ... See more keywords