Allosteric Molecular Switches in Metabotropic Glutamate Receptors
Sign Up to like & getrecommendations! Published in 2020 at "Chemmedchem"
DOI: 10.1002/cmdc.202000444
Abstract: Metabotropic glutamate receptors (mGlu) are class C G protein‐coupled receptors of eight subtypes that are omnipresently expressed in the central nervous system. mGlus have relevance in several psychiatric and neurological disorders, therefore they raise considerable interest… read more here.
Keywords: allosteric molecular; metabotropic glutamate; switches metabotropic; molecular switches ... See more keywords
Cell-Based Enzyme-Linked Immunosorbent Assay (Cell-ELISA) Analysis of Native and Recombinant Glutamate Receptors.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9077-1_4
Abstract: Glutamate receptors (GluRs) located primarily on the membranes of neurons and glial cells are responsible for excitatory synaptic transmission in the central nervous system. The transport of GluRs to the cell surface is a highly… read more here.
Keywords: cell based; based enzyme; glutamate receptors; cell ... See more keywords
Modulatory function of NMDA glutamate receptor on MC3/MC4 receptors agonist-induced hypophagia in neonatal meat-type chicken
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary Research Communications"
DOI: 10.1007/s11259-017-9693-x
Abstract: Melanocortin 3 and 4 receptors (MC3R and MC4R) are known as the main receptors for melanocortin-induced hypophagia in mammalian and poultry. Also, central glutamatergic system has mediatory role on function of the melanocortin system in… read more here.
Keywords: mc3 mc4; receptors antagonist; mc4 receptors; glutamate receptors ... See more keywords
Guanosine and GMP increase the number of granular cerebellar neurons in culture: dependence on adenosine A2A and ionotropic glutamate receptors
Sign Up to like & getrecommendations! Published in 2019 at "Purinergic Signalling"
DOI: 10.1007/s11302-019-09677-y
Abstract: The guanine-based purines (GBPs) have essential extracellular functions such as modulation of glutamatergic transmission and trophic effects on neurons and astrocytes. We previously showed that GBPs, such as guanosine-5′-monophosphate (GMP) or guanosine (GUO), promote the… read more here.
Keywords: cerebellar neurons; gmp; number; glutamate receptors ... See more keywords
Control of neuronal excitability by Group I metabotropic glutamate receptors
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Reviews"
DOI: 10.1007/s12551-017-0301-7
Abstract: Metabotropic glutamate (mGlu) receptors couple through G proteins to regulate a large number of cell functions. Eight mGlu receptor isoforms have been cloned and classified into three Groups based on sequence, signal transduction mechanisms and… read more here.
Keywords: glutamate receptors; metabotropic glutamate; group metabotropic; metabotropic ... See more keywords
Treadmill exercise overcomes memory deficits related to synaptic plasticity through modulating ionic glutamate receptors
Sign Up to like & getrecommendations! Published in 2021 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2021.113502
Abstract: Neuronal death and synaptic loss are major pathogensis of Alzheimer's disease (AD), which may be related to the ionic glutamate receptors abnormality. Ionic glutamate receptors are important postsynaptic membrane receptors that regulate excitatory synaptic transmission… read more here.
Keywords: ionic glutamate; exercise; mice; glutamate receptors ... See more keywords
Glucose transporter type 1 deficiency syndrome associated with autoantibodies to glutamate receptors
Sign Up to like & getrecommendations! Published in 2020 at "Brain and Development"
DOI: 10.1016/j.braindev.2020.05.010
Abstract: BACKGROUND The clinical spectrum of glucose transporter type 1 deficiency syndrome (GLUT1DS) has broadened, with increasing recognition of a milder phenotype. Antibodies targeting the subunits of glutamate receptors (GluRs), including GluN1, GluN2B, and GluD2, have… read more here.
Keywords: glucose transporter; deficiency syndrome; glutamate receptors; type deficiency ... See more keywords
Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Pharmacology"
DOI: 10.1016/j.coph.2017.12.001
Abstract: HighlightsAlzheimer's disease is an incurable neurodegenerative disease causing such a severe dementia to interfere with daily life.Pathognomonic lesions of Alzheimer's disease are plaques of &bgr;‐amyloid, neurofibrillary tangles and neuronal loss.Alterations of the glutamatergic transmission contribute… read more here.
Keywords: alzheimer disease; metabotropic glutamate; glutamate receptors; disease ... See more keywords
Metabotropic glutamate receptors: targets for neuroprotective therapies in Parkinson disease.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2018.03.004
Abstract: Metabotropic glutamate receptors (mGluRs) are heavily expressed throughout the basal ganglia (BG), where they modulate neuronal excitability, transmitter release and long term synaptic plasticity. Therefore, targeting specific mGluR subtypes by means of selective drugs could… read more here.
Keywords: glutamate receptors; metabotropic glutamate; parkinson disease;
Synthesis of an allosteric modulator of ionotropic glutamate receptors
Sign Up to like & getrecommendations! Published in 2020 at "Mendeleev Communications"
DOI: 10.1016/j.mencom.2020.03.008
Abstract: Synthesis of 6-[4-methoxy-3-(pyrrolidin-1-ylmethyl)benzyl]-1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13,11]tetradecane-4,8,12-trione has been carried out and optimized. In vitro studies using electrophysiological patch clamp technique have revealed a negative effect of this compound on kainateinduced currents in Purkinje neurons in a wide range… read more here.
Keywords: allosteric modulator; modulator ionotropic; glutamate receptors; ionotropic glutamate ... See more keywords
Glutamate receptors and white matter stroke
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.11.031
Abstract: White matter (WM) damage during ischemia occurs at multiple sites including myelin, oligodendrocytes, astrocytes and axons. A major driver of WM demise is excitoxicity as a consequence of excessive glutamate release by vesicular and non-vesicular… read more here.
Keywords: glutamate receptors; receptors white; matter stroke; white matter ... See more keywords