Utility of Imaging-Based Biomarkers for Glutamate-Targeted Drug Development in Psychotic Disorders: A Randomized Clinical Trial
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DOI: 10.1001/jamapsychiatry.2017.3572
Abstract: Importance Despite strong theoretical rationale and preclinical evidence, several glutamate-targeted treatments for schizophrenia have failed in recent pivotal trials, prompting questions as to target validity, compound inadequacy, or lack of target engagement. A key limitation… read more here.
Keywords: trial; glutamate targeted; utility; randomized clinical ... See more keywords