G protein‐coupled receptor 37‐like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23198
Abstract: We show that the G protein‐coupled receptor GPR37‐like 1 (GPR37L1) is expressed in most astrocytes and some oligodendrocyte precursors in the mouse central nervous system. This contrasts with GPR37, which is mainly in mature oligodendrocytes.… read more here.
Keywords: astrocyte glutamate; protein coupled; coupled receptor; glutamate transporters ... See more keywords
DNA Methylation-Dependent Gene Expression Regulation of Glutamate Transporters in Cultured Radial Glial Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular neurobiology"
DOI: 10.1007/s12035-022-02746-1
Abstract: Exposure to xenobiotics has a significant impact in brain physiology that could be liked to an excitotoxic process induced by a massive release of the main excitatory neurotransmitter, L-glutamate. Overstimulation of extra-synaptic glutamate receptors, mainly… read more here.
Keywords: glutamate; gene expression; glutamate transporters; dna methylation ... See more keywords
Müller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.05.011
Abstract: SUMMARY Retinal waves, the spontaneous patterned neural activities propagating among developing retinal ganglion cells (RGCs), instruct the activity-dependent refinement of visuotopic maps. Although it is known that the wave is initiated successively by amacrine cells… read more here.
Keywords: glial cells; ampa receptors; glutamate transporters; ller glial ... See more keywords
Semi-quantitative distribution of excitatory amino acid (glutamate) transporters 1–3 (EAAT1-3) and the cystine-glutamate exchanger (xCT) in the adult murine spinal cord
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2020.104811
Abstract: Proper glutamatergic neurotransmission requires a balance between glutamate release and removal. The removal is mainly catalyzed by the glutamate transporters EAAT1-3, while the glutamate-cystine exchanger (system xc- with specific subunit xCT) represents one of the… read more here.
Keywords: xct; glutamate transporters; glutamate; distribution ... See more keywords
The effects of short time hyperoxia on glutamate concentration and glutamate transporters expressions in brain of neonatal rats
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.136013
Abstract: Preterm infants often suffer from impaired postnatal brain development, and glutamate excitotoxicity is identified as a pivotal mechanism of hyperoxia-induced neurological abnormality. We aimed to investigate the effect of short time hyperoxia on glutamate homeostasis… read more here.
Keywords: time; brain; glutamate transporters; cerebellum ... See more keywords
Transient Kinetics Reveal Mechanism and Voltage Dependence of Inhibitor and Substrate Binding to Glutamate Transporters.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00194
Abstract: Plasma-membrane glutamate transporters of the excitatory amino acid transporter (EAAT) family are important for maintaining a low glutamate concentration in the extracellular space of the mammalian brain. Glutamate is believed to be transported in its… read more here.
Keywords: substrate binding; inhibitor; glutamate transporters; glutamate ... See more keywords
Milestone Review: Excitatory amino acid transporters – Beyond their expected function
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15809
Abstract: Glutamate is the major excitatory neurotransmitter in the vertebrate brain, it is critically involved in the function and dysfunction of the central nervous system. The molecular cloning of its ionotropic receptors in the last decade… read more here.
Keywords: system; function; glutamate; milestone review ... See more keywords
Glutamate Transporters in Hippocampal LTD/LTP: Not Just Prevention of Excitotoxicity
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00357
Abstract: Glutamate uptake is a process mediated by sodium-dependent glutamate transporters, preventing glutamate spillover from the synapse. Typically, astrocytes express higher amounts of glutamate transporters, thus being responsible for most of the glutamate uptake; nevertheless, neurons… read more here.
Keywords: glutamate uptake; transporters hippocampal; excitotoxicity; hippocampal ltd ... See more keywords
A mini-review of the role of vesicular glutamate transporters in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1118078
Abstract: Parkinson’s disease (PD) is a common neurodegenerative disease implicated in multiple interacting neurotransmitter pathways. Glutamate is the central excitatory neurotransmitter in the brain and plays critical influence in the control of neuronal activity. Impaired Glutamate… read more here.
Keywords: glutamate; role; parkinson disease; vesicular glutamate ... See more keywords