Constitutive downregulation protein kinase C epsilon in hSOD1G93A astrocytes influences mGluR5 signaling and the regulation of glutamate uptake
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23279
Abstract: Accumulating evidence indicates that motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is a non‐cell‐autonomous process and that impaired glutamate clearance by astrocytes, leading to excitotoxicity, could participate in progression of the disease. In astrocytes… read more here.
Keywords: glutamate uptake; glutamate; mglur5 activation; regulation glutamate ... See more keywords
RETRACTED ARTICLE: Astrocytes Regulate Differentiation and Glutamate Uptake of Glioma Stem Cells via Formyl Peptide Receptor
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00886-3
Abstract: The role of astrocytes on glutamate release and differentiation of glioma stem cells (GSCs) remains unknown. We investigated glutamate release, proliferation, and differentiation of GSCs after indirect incubation with astrocytes in vitro, including morphology change,… read more here.
Keywords: stem cells; glioma stem; glutamate uptake; differentiation ... See more keywords
Rutin improves glutamate uptake and inhibits glutamate excitotoxicity in rat brain slices
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DOI: 10.1007/s11033-021-06145-y
Abstract: Rutin is an important flavonoid consumed in the daily diet. It is also known as vitamin P and has been extensively investigated due to its pharmacological properties. On the other hand, neuronal death induced by… read more here.
Keywords: glutamate uptake; brain; wistar rats; glutamate ... See more keywords
Platelet glutamate uptake and Th1 cells inversely correlate in relapsing/remitting and in progressive multiple sclerosis.
Sign Up to like & getrecommendations! Published in 2020 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2020.102007
Abstract: BACKGROUND High affinity sodium-dependent Excitatory Amino Acid Transporters (EAAT), present in glial and neuron cells, clear around 90% of the synaptic cleft released glutamate, and their impaired activity seem to be critical for many neurodegenerative… read more here.
Keywords: glutamate uptake; platelet glutamate; multiple sclerosis; th1 cells ... See more keywords
PAR1 activation induces rapid changes in glutamate uptake and astrocyte morphology
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DOI: 10.1038/srep43606
Abstract: The G-protein coupled, protease-activated receptor 1 (PAR1) is a membrane protein expressed in astrocytes. Fine astrocytic processes are in tight contact with neurons and blood vessels and shape excitatory synaptic transmission due to their abundant… read more here.
Keywords: glutamate uptake; induces rapid; par1 activation; activation ... See more keywords
Glutamate Transporters in Hippocampal LTD/LTP: Not Just Prevention of Excitotoxicity
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DOI: 10.3389/fncel.2019.00357
Abstract: Glutamate uptake is a process mediated by sodium-dependent glutamate transporters, preventing glutamate spillover from the synapse. Typically, astrocytes express higher amounts of glutamate transporters, thus being responsible for most of the glutamate uptake; nevertheless, neurons… read more here.
Keywords: glutamate uptake; transporters hippocampal; excitotoxicity; hippocampal ltd ... See more keywords
Astrocyte Glutamate Uptake and Signaling as Novel Targets for Antiepileptogenic Therapy
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2020.01006
Abstract: Astrocytes regulate and respond to extracellular glutamate levels in the central nervous system (CNS) via the Na+-dependent glutamate transporters glutamate transporter-1 (GLT-1) and glutamate aspartate transporter (GLAST) and the metabotropic glutamate receptors (mGluR) 3 and… read more here.
Keywords: astrocyte glutamate; glutamate uptake; metabotropic glutamate; uptake signaling ... See more keywords
Glutamate Uptake Is Not Impaired by Hypoxia in a Culture Model of Human Fetal Neural Stem Cell-Derived Astrocytes
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DOI: 10.3390/genes13030506
Abstract: Hypoxic ischemic injury to the fetal and neonatal brain is a leading cause of death and disability worldwide. Although animal and culture studies suggest that glutamate excitotoxicity is a primary contributor to neuronal death following… read more here.
Keywords: culture; derived astrocytes; stem cell; neural stem ... See more keywords