Striatal H3K27 Acetylation Linked to Glutamatergic Gene Dysregulation in Human Heroin Abusers Holds Promise as Therapeutic Target
Sign Up to like & getrecommendations! Published in 2017 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2016.09.015
Abstract: BACKGROUND Opiate abuse and overdose reached epidemic levels in the United States. However, despite significant advances in animal and in vitro models, little knowledge has been directly accrued regarding the neurobiology of the opiate-addicted human… read more here.
Keywords: h3k27 acetylation; heroin; glutamatergic gene; heroin self ... See more keywords
The Role of Glutamatergic Gene Polymorphisms in the Clinical Phenotypes of Schizophrenia
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14030575
Abstract: Background: Personal variations in genetic risk for schizophrenia relate to its phenotypic heterogeneity—both in disorder development and clinical manifestations. Abnormal glutamatergic neurotransmitter system functioning is integrated in the pathogenesis of schizophrenia. Methods: A sample of… read more here.
Keywords: glutamatergic gene; gene polymorphisms; polymorphisms clinical; role glutamatergic ... See more keywords