Chemogenetic activation of glutamatergic neurons in the motor cortex promotes functional recovery after ischemic stroke in rats
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.10.029
Abstract: HighlightsChemogenetic activation of the motor cortex decreased the neurological deficit scores.Chemogenetic activation of the motor cortex increased the grip test scores and the hanging time.Chemogenetic activation of the motor cortex improved the recovery of spatial… read more here.
Keywords: recovery; glutamatergic neurons; motor; activation ... See more keywords
Glutamatergic Ventral Pallidal Neurons Modulate Activity of the Habenula–Tegmental Circuitry and Constrain Reward Seeking
Sign Up to like & getrecommendations! Published in 2018 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2018.01.003
Abstract: BACKGROUND The ability to appropriately integrate and respond to rewarding and aversive stimuli is essential for survival. The ventral pallidum (VP) plays a critical role in processing both rewarding and aversive stimuli. However, the VP… read more here.
Keywords: reward seeking; constrain reward; glutamatergic neurons; habenula ... See more keywords
Glutamatergic lateral hypothalamus promotes defensive behaviors
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.108239
Abstract: The glutamatergic lateral hypothalamus (LH) has been implicated in a variety of behaviors, such as evasion and feeding, while its role in defensive behaviors and relevant neurocircuits remains unclear. Here, we demonstrate that glutamatergic LH… read more here.
Keywords: glutamatergic; glutamatergic neurons; glutamatergic lateral; defensive behaviors ... See more keywords
Impaired anandamide/palmitoylethanolamide signaling in hippocampal glutamatergic neurons alters synaptic plasticity, learning, and emotional responses
Sign Up to like & getrecommendations! Published in 2018 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-018-0274-7
Abstract: Endocannabinoid signaling via anandamide (AEA) is implicated in a variety of neuronal functions and considered a promising therapeutic target for numerous emotion-related disorders. The major AEA degrading enzyme is fatty acid amide hydrolase (FAAH). Genetic… read more here.
Keywords: emotional responses; term; glutamatergic neurons; learning emotional ... See more keywords
Common schizophrenia risk variants are enriched in open chromatin regions of human glutamatergic neurons
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19319-2
Abstract: The chromatin landscape of human brain cells encompasses key information to understanding brain function. Here we use ATAC-seq to profile the chromatin structure in four distinct populations of cells (glutamatergic neurons, GABAergic neurons, oligodendrocytes, and… read more here.
Keywords: schizophrenia; chromatin; chromatin regions; glutamatergic neurons ... See more keywords
CB1 Receptor Activation on VgluT2-Expressing Glutamatergic Neurons Underlies Δ9-Tetrahydrocannabinol (Δ9-THC)-Induced Aversive Effects in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-12399-z
Abstract: Cannabis can be rewarding or aversive. Cannabis reward is believed to be mediated by activation of cannabinoid CB1 receptors (CB1Rs) on GABAergic neurons that disinhibit dopaminergic neurons in the ventral tegmental area (VTA). However, little… read more here.
Keywords: vglut2 expressing; tetrahydrocannabinol thc; glutamatergic neurons; aversive effects ... See more keywords
Histamine H2 receptor deficit in glutamatergic neurons contributes to the pathogenesis of schizophrenia.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2207003120
Abstract: Schizophrenia is a serious mental disorder, and existing antipsychotic drugs show limited efficacy and cause unwanted side effects. The development of glutamatergic drugs for schizophrenia is currently challenging. Most functions of histamine in the brain… read more here.
Keywords: h2r; glutamatergic neurons; pathogenesis schizophrenia; receptor ... See more keywords
GABAA Receptors and Maternally Derived Taurine Regulate the Temporal Specification of Progenitors of Excitatory Glutamatergic Neurons in the Mouse Developing Cortex.
Sign Up to like & getrecommendations! Published in 2021 at "Cerebral cortex"
DOI: 10.1093/cercor/bhab106
Abstract: Temporal specification of the neural progenitors (NPs) producing excitatory glutamatergic neurons is essential for histogenesis of the cerebral cortex. Neuroepithelial cells, the primary NPs, transit to radial glia (RG). To coincide with the transition, NPs… read more here.
Keywords: excitatory glutamatergic; cortex; glutamatergic neurons; gabaa receptors ... See more keywords
Glutamate Is a Wake-Active Neurotransmitter in Drosophila melanogaster.
Sign Up to like & getrecommendations! Published in 2017 at "Sleep"
DOI: 10.1093/sleep/zsw046
Abstract: Introduction In mammals, there is evidence that glutamate has a role as a wake-active neurotransmitter. So using video-based analysis of Drosophila behavior, we undertook a study to examine if glutamate, which has been previously shown… read more here.
Keywords: wake active; active neurotransmitter; drosophila; glutamatergic neurons ... See more keywords
Regulation of sleep homeostasis mediator adenosine by basal forebrain glutamatergic neurons
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.abb0556
Abstract: Sleep and basal forebrain activity Different patterns of neural activity in the brain control the sleep-wake cycle. However, how this activity contributes to sleep homeostasis remains largely unknown. Adenosine in the basal forebrain is a… read more here.
Keywords: sleep homeostasis; glutamatergic neurons; increase; adenosine ... See more keywords
Glutamatergic neurons in lateral hypothalamus play a vital role in acupuncture preconditioning to alleviate MIRI.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurophysiology"
DOI: 10.1152/jn.00424.2022
Abstract: Myocardial ischemia-reperfusion injury (MIRI) has high morbidity and mortality worldwide. Increasing evidence has shown that electro-acupuncture (EA) plays a critical role in alleviating MIRI. The aim of this study is to investigate whether glutamatergic neurons… read more here.
Keywords: lateral hypothalamus; acupuncture; role; miri ... See more keywords