4-phenylselenyl-7-chloroquinoline, a novel multitarget compound with anxiolytic activity: Contribution of the glutamatergic system.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2016.10.007
Abstract: A growing body of evidence demonstrates that quinoline compounds have attracted much attention in the field of drug development. Accordingly, 4-phenylselenyl-7-chloroquinoline (4-PSQ) is a new quinoline derivative containing selenium, which showed a potential antioxidant, antinociceptive… read more here.
Keywords: glutamatergic system; psq; anxiolytic like; activity ... See more keywords
Resilience Dysregulation in Major Depressive Disorder: Focus on 
Glutamatergic Imbalance and Microglial Activation
Sign Up to like & getrecommendations! Published in 2018 at "Current Neuropharmacology"
DOI: 10.2174/1570159x15666170630164715
Abstract: Background: Many studies have been shown an important role of glutamatergic system as well microglial activa-tion in the pathophysiology of major depressive disorder (MDD). In humans most resistant to the development of psychiat-ric disorders, including… read more here.
Keywords: glutamatergic system; depressive disorder; major depressive; resilience ... See more keywords
Glutamatergic system components as potential biomarkers and therapeutic targets in cancer in non-neural organs
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1029210
Abstract: Glutamate is one of the most abundant amino acids in the blood. Besides its role as a neurotransmitter in the brain, it is a key substrate in several metabolic pathways and a primary messenger that… read more here.
Keywords: neural organs; glutamatergic system; physiology; cancer ... See more keywords
Identification of miRNA–mRNA regulatory network associated with the glutamatergic system in post-traumatic epilepsy rats
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.1102672
Abstract: Background Glutamate is one of the most important excitatory neurotransmitters in the mammalian brain and is involved in a variety of neurological disorders. Increasing evidence also shows that microRNA (miRNA) and mRNA pairs are engaged… read more here.
Keywords: system; mirna mrna; differentially expressed; glutamatergic system ... See more keywords
Glutamatergic System in Depression and Its Role in Neuromodulatory Techniques Optimization
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.886918
Abstract: Depressive disorders are among the most common psychiatric conditions and contribute to significant morbidity. Even though the use of antidepressants revolutionized the management of depression and had a tremendous positive impact on the patient's outcome,… read more here.
Keywords: depression role; role; depression; depressive disorders ... See more keywords
Genes of the Glutamatergic System and Tardive Dyskinesia in Patients with Schizophrenia
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12071521
Abstract: Background: Tardive dyskinesia (TD) is an extrapyramidal side effect of the long-term use of antipsychotics. In the present study, the role of glutamatergic system genes in the pathogenesis of total TD, as well as two… read more here.
Keywords: system; tardive dyskinesia; significant associations; patients schizophrenia ... See more keywords
Novel Antidepressant Mechanism of Ginsenoside Rg1 in Regulating the Dysfunction of the Glutamatergic System in Astrocytes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010575
Abstract: Ginsenoside Rg1, a traditional Chinese medicine monomer, has been shown to have antidepressant effects. We previously found that Rg1 exerts antidepressant effects by improving the gap junction channels (GJCs) dysfunction; however, the downstream mechanisms through… read more here.
Keywords: glutamatergic system; dysfunction; ginsenoside rg1;