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   Articles with "glutaminase" as a keyword



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Identification and characterization of a novel glutaminase inhibitor.

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recommendations! Published in 2021 at "FEBS open bio"

DOI: 10.1002/2211-5463.13319

Abstract: In humans, there are two forms of glutaminase (GLS), designated GLS1 and GLS2. These enzymes catalyze the conversion of glutamine to glutamate. GLS1 exists as two isozymes: kidney glutaminase (KGA) and glutaminase C (GAC). Several… read more here.

Keywords: characterization novel; inhibitor; glutaminase; novel glutaminase ... See more keywords
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Construction of a thermoresponsive magnetic porous polymer membrane enzyme reactor for glutaminase kinetics study

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recommendations! Published in 2018 at "Analytical and Bioanalytical Chemistry"

DOI: 10.1007/s00216-018-1169-5

Abstract: AbstractFabrication of polymer membranes with nanopores and a confinement effect toward enzyme immobilization has been an enabling endeavor. In the work reported here, an enzyme reactor based on a thermoresponsive magnetic porous block copolymer membrane… read more here.

Keywords: magnetic porous; glutaminase; enzyme reactor; reactor ... See more keywords
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Glutaminase 1 in mandarin fish Siniperca chuatsi: Molecular characterization, expression pattern and function involving in virus replication

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recommendations! Published in 2020 at "Aquaculture"

DOI: 10.1016/j.aquaculture.2020.734924

Abstract: Abstract Glutaminolysis plays a critical role in viral replication. While Glutaminase 1 (GLS1) is a key enzyme in the glutaminolysis pathway. However the characteristic and function of GLS1 in mandarin fish during viral infection remains… read more here.

Keywords: glutaminase; mandarin fish; gls1; expression ... See more keywords
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Glutaminase‐1 stimulates the proliferation, migration, and survival of human endothelial cells

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recommendations! Published in 2018 at "Biochemical Pharmacology"

DOI: 10.1016/j.bcp.2018.08.032

Abstract: Graphical abstract Figure. No Caption available. Abstract Glutaminase‐1 (GLS1) is a mitochondrial enzyme found in endothelial cells (ECs) that metabolizes glutamine to glutamate and ammonia. Although glutaminolysis modulates the function of human umbilical vein ECs,… read more here.

Keywords: migration survival; proliferation migration; glutaminase; gls1 ... See more keywords

Increasing antioxidant activities of the glutamine-cysteine mixture by the glutaminase from Bacillus amyloliquefaciens.

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recommendations! Published in 2019 at "Food chemistry"

DOI: 10.1016/j.foodchem.2019.125701

Abstract: In this study, we found that glutaminase from Bacillus amyloliquefaciens could increase antioxidant activities of Gln-Cys mixture, demonstrated by the higher superoxide anion and DPPH radical scavenging activities, Fe2+-chelating and reducing power. According to UPLC-Q-TOF-MS/MS… read more here.

Keywords: glutaminase bacillus; glutaminase; cys; antioxidant activities ... See more keywords

Increased Expression of Glutaminase in Osteoblasts Promotes Macrophage Recruitment in Periapical Lesions

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recommendations! Published in 2017 at "Journal of Endodontics"

DOI: 10.1016/j.joen.2016.11.005

Abstract: Introduction Recently, we have shown that tissue hypoxia stimulates the progression of periapical lesions by up‐regulating glycolysis‐dependent apoptosis of osteoblasts. Other facets of hypoxia‐induced metabolic reprogramming in disease pathogenesis require further investigation. In this study,… read more here.

Keywords: periapical lesions; glutaminase; macrophage recruitment; gls1 ... See more keywords
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An l-glutaminase enzyme reactor based on porous bamboo sticks and its application in enzyme inhibitors screening.

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recommendations! Published in 2019 at "Talanta"

DOI: 10.1016/j.talanta.2019.120126

Abstract: Inspired by the porous and fibrous structure of commercially available bamboo, herein we created an l-glutaminase enzyme reactor based on bamboo sticks. The enzyme was immobilized onto the bamboo sticks through a glutaraldehyde modification to… read more here.

Keywords: glutaminase; enzyme reactor; bamboo sticks; bamboo ... See more keywords

Glutaminase Affects the Transcriptional Activity of Peroxisome Proliferator-Activated Receptor γ (PPARγ) via Direct Interaction.

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recommendations! Published in 2018 at "Biochemistry"

DOI: 10.1021/acs.biochem.8b00773

Abstract: Phosphate-activated glutaminases catalyze the deamidation of glutamine to glutamate and play key roles in several physiological and pathological processes. In humans, GLS encodes two multidomain splicing isoforms: KGA and GAC. In both isoforms, the canonical… read more here.

Keywords: ppar; peroxisome proliferator; glutaminase; proliferator activated ... See more keywords
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Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties.

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recommendations! Published in 2020 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.0c01398

Abstract: Inhibition of glutaminase-1 (GLS-1) hampers the proliferation of tumor cells reliant on glutamine. Known glutaminase inhibitors have potential limitations, and in vivo exposures are potentially limited due to poor physicochemical properties. We initiated a GLS-1… read more here.

Keywords: glutaminase gls; inhibitor; glutaminase; gls inhibitor ... See more keywords
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Microbes Producing L-Asparaginase free of Glutaminase and Urease isolated from Extreme Locations of Antarctic Soil and Moss

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recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-018-38094-1

Abstract: L-Asparaginase (L-asparagine aminohydrolase, E.C. 3.5.1.1) has been proven to be competent in treating Acute Lymphoblastic Leukaemia (ALL), which is widely observed in paediatric and adult groups. Currently, clinical L-Asparaginase formulations are derived from bacterial sources… read more here.

Keywords: asparaginase free; glutaminase urease; free glutaminase; glutaminase ... See more keywords

Brachyantheraoside A8, a new natural nor-oleanane triterpenoid as a kidney-type glutaminase inhibitor from Stauntonia brachyanthera

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recommendations! Published in 2017 at "RSC Advances"

DOI: 10.1039/c7ra11270j

Abstract: With the aim of finding a better kidney-type glutaminase (KGA) inhibitor with potential anti-cancer properties, 18 nor-oleanane triterpenoids from Stauntonia brachyanthera, including 2 new ones, were screened against KGA. The structure-based virtual ligand screening identified… read more here.

Keywords: inhibitor; stauntonia brachyanthera; glutaminase; type glutaminase ... See more keywords