Genome‐Wide CRISPR/Cas9 Library Screening Revealed Dietary Restriction of Glutamine in Combination with Inhibition of Pyruvate Metabolism as Effective Liver Cancer Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202104
Abstract: Hepatocellular carcinoma (HCC) is the second most lethal cancer worldwide. Glutamine is an essential, extracellular nutrient which supports HCC growth. Dietary glutamine deficiency may be a potential therapeutic approach for HCC. HCC cells overcome metabolic… read more here.
Keywords: glutamine; treatment; hcc; pyruvate metabolism ... See more keywords
ASCT2 overexpression is associated with poor survival of OSCC patients and ASCT2 knockdown inhibited growth of glutamine‐addicted OSCC cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.2965
Abstract: Alanine‐serine‐cysteine transporter 2 (ASCT2), a major glutamine transporter, is essential for cell growth and tumor development in a variety of cancers. However, the clinicopathological significance and pathological role of ASCT2 in OSCC (oral squamous cell… read more here.
Keywords: associated poor; poor survival; asct2 overexpression; growth ... See more keywords
The longitudinal influence of tDCS on occipital GABA and glutamate/glutamine levels in episodic migraineurs
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25161
Abstract: This study investigated differences in the concentration of gamma‐aminobutyric acid (GABA) and the combination of glutamine and glutamate (as GLX) in the early visual cortex of patients with episodic migraine and the influence of transcranial… read more here.
Keywords: period; glutamate; influence; tdcs ... See more keywords
Glutamine Induced High-Quality Perovskite Film to Improve the Efficiency of NIR Perovskite Light-Emitting Diodes.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202207520
Abstract: Formamidine lead iodide (FAPbI3 ) is an important material for realizing high-performance near-infrared light-emitting diodes (NIR-LEDs). However, due to the uncontrollable growth of solution-processed films which usually causes low coverage, and poor surface morphology, the… read more here.
Keywords: perovskite film; emitting diodes; film; glutamine ... See more keywords
Acute glutamine supplementation does not improve 20-km self-paced cycling performance in the heat
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Applied Physiology"
DOI: 10.1007/s00421-019-04234-2
Abstract: The premise of this study was to investigate the effect of acute glutamine supplementation on 20 km time trial cycling performance in the heat, neuromuscular function, inflammation and endotoxemia. Twelve cyclists completed two, 20-km time… read more here.
Keywords: heat; glutamine supplementation; glutamine; performance heat ... See more keywords
Both high and low plasma glutamine levels predict mortality in critically ill patients
Sign Up to like & getrecommendations! Published in 2017 at "Surgery Today"
DOI: 10.1007/s00595-017-1511-0
Abstract: PurposePlasma amino acids are important indicators for understanding human kinetics and amino acid dynamics. We aimed to investigate the association between the plasma glutamine levels and the mortality rates and determine whether plasma glutamine can… read more here.
Keywords: glutamine levels; group; mortality; critically ill ... See more keywords
Alanyl-glutamine but not glycyl-glutamine improved the proliferation of enterocytes as glutamine substitution in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Amino Acids"
DOI: 10.1007/s00726-017-2460-z
Abstract: The synthetic dipeptides alanyl-glutamine (Ala-Gln) and glycyl-glutamine (Gly-Gln) are used as Gln substitution to provide energy source in the gastrointestinal tract due to their high solubility and stability. This study aimed to investigate the effects… read more here.
Keywords: gln treatment; gly gln; ala gln; gln ... See more keywords
Oxidation of energy substrates in tissues of largemouth bass (Micropterus salmoides)
Sign Up to like & getrecommendations! Published in 2020 at "Amino Acids"
DOI: 10.1007/s00726-020-02871-y
Abstract: This study tested the hypothesis that amino acids are oxidized at higher rates than glucose and palmitate for ATP production in tissues of largemouth bass (LMB, a carnivorous fish). Slices (10 to 50 mg) of… read more here.
Keywords: tissues largemouth; plus 14c; largemouth bass; mixture ... See more keywords
Excess glutamine does not alter myotube metabolism or insulin sensitivity
Sign Up to like & getrecommendations! Published in 2022 at "Amino Acids"
DOI: 10.1007/s00726-022-03131-x
Abstract: Glutamine is an amino acid previously linked with improved skeletal muscle metabolism and insulin signaling, however, past observations often use cell culture models with only supraphysiological concentrations. Additionally, past reports have yet to simultaneously investigate… read more here.
Keywords: glutamine; metabolism insulin; insulin signaling; insulin ... See more keywords
Development of Optical Biosensor for the Detection of Glutamine in Human Biofluids Using Merocyanine Dye.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of fluorescence"
DOI: 10.1007/s10895-022-02937-y
Abstract: Merocyanine dye based fluorescent organic compound has been synthesized for the detection of glutamine. The probe showed remarkable fluorescent intensity with glutamine through ICT (Intermolecular Charge Transfer Mechanism). Hence, it is tested for the detection… read more here.
Keywords: human biofluids; detection glutamine; merocyanine dye; glutamine ... See more keywords
Glutamine Addiction In Gliomas
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemical Research"
DOI: 10.1007/s11064-017-2212-1
Abstract: Cancer cells develop and succeed by shifting to different metabolic programs compared with their normal cell counterparts. One of the classical hallmarks of cancer cells is their higher glycolysis rate and lactate production even in… read more here.
Keywords: addiction; glutamine addiction; cancer cells; glutamine ... See more keywords