Genomic evidence for dysregulated glutamine metabolism in the asthmatic airway epithelium
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Allergy"
DOI: 10.1002/clt2.12178
Abstract: To the Editor, Airway epithelial cells (AECs) play a critical role in lung tissue homeostasis and disease. In asthma, AECs can promote the development of airway inflammation and remodeling through the secretion and regulation of… read more here.
Keywords: metabolism; glutamine metabolism; asthma; differentially expressed ... See more keywords
miR-9-5p inhibits pancreatic cancer cell proliferation, invasion and glutamine metabolism by targeting GOT1.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.12.114
Abstract: MicroRNAs (miRNAs) play crucial roles in the pancreatic carcinogenesis and progression. In the present study, we found that miR-9-5p was significantly downregulated in pancreatic cancer tissues and cell lines. The expression levels of miR-9-5p were… read more here.
Keywords: invasion; mir; glutamine metabolism; pancreatic cancer ... See more keywords
2007 – DIFFERENTIAL ALTERNATIVE POLYADENYLATION LANDSCAPES MEDIATE HEMATOPOIETIC STEM CELL ACTIVATION AND REGULATE GLUTAMINE METABOLISM
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2020.09.169
Abstract: Alternative polyadenylation (APA) is emerging as an important regulatory mechanism of RNA and protein isoform expression by controlling 3’-untranslated region (3’-UTR) composition. The relevance of APA in stem cell hierarchies in vivo remains elusive. Using… read more here.
Keywords: stem cell; glutamine metabolism; alternative polyadenylation; cell ... See more keywords
Effects of l-theanine on glutamine metabolism in enterotoxigenic Escherichia coli (E44813)-stressed and non-stressed rats
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2019.103670
Abstract: Abstract l -theanine, a non-protein-derived amino acid, is widely used as a functional ingredient in foods. Here, we evaluated the in vivo effects of l -theanine on glutamine metabolism in healthy rats and in a… read more here.
Keywords: escherichia coli; theanine glutamine; glutamine metabolism; effects theanine ... See more keywords
Targeting Glutamine Metabolism and PD-L1: A Novel Anti-tumor Pas de Deux.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.11.005
Abstract: In this issue of Molecular Cell, Byun et al. (2020) find that the dual targeting of glutamine metabolism and the PD-L1 checkpoint inhibitor augments anti-tumor immunity. Mechanistically, decreased glutamine availability attenuated S-glutathionylation of SERCA, resulting in… read more here.
Keywords: glutamine metabolism; anti tumor; targeting glutamine; metabolism novel ... See more keywords
Mitochondrial GPT2 plays a pivotal role in metabolic adaptation to the perturbation of mitochondrial glutamine metabolism
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-0751-4
Abstract: Cancer cells exhibit metabolic dependence on mitochondrial glutamine metabolism that provides them with the substrates required for rapid proliferation. Despite the extensive efforts to target this glutamine addiction for therapeutic purposes, the adaptive metabolic responses… read more here.
Keywords: mitochondrial glutamine; glutamine metabolism; inhibition; gpt2 ... See more keywords
Engineering Tumour Cell-Binding Synthetic Polymers with Sensing Dense Transporters Associated with Aberrant Glutamine Metabolism
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06438-y
Abstract: Increased glutamine uptake toward the elevated glutaminolysis is one of the hallmarks of tumour cells. This aberrant glutamine metabolism has recently attracted considerable attention as a diagnostic and therapeutic target. Herein, we developed glutamine-functionalized polymer… read more here.
Keywords: tumour cells; metabolism; glutamine metabolism; aberrant glutamine ... See more keywords
Penicillin induces alterations in glutamine metabolism in Streptococcus pneumoniae
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-15035-y
Abstract: Penicillin is a bactericidal antibiotic that inhibits the synthesis of the peptidoglycan by targeting penicillin-binding proteins. This study aimed to assess through transcriptional profiling the stress response of S. pneumoniae strains after exposure to lethal… read more here.
Keywords: pneumoniae penicillin; glutamine metabolism; penicillin induces; penicillin ... See more keywords
A biomimetic ZIF nanoagent for synergistic regulation of glutamine metabolism and intracellular acidosis of cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc05903c
Abstract: A homotypic cancer cell membrane camouflaged zeolitic imidazolate framework (ZIF)-based nanoagent with co-loading of two inhibitors was developed, which could suppress the efflux of protons to induce intracellular acidic stress and down-regulate glutamine metabolism to… read more here.
Keywords: acidosis; glutamine metabolism; zif; cancer ... See more keywords
Zeolitic imidazolate framework-based nanoparticles for the cascade enhancement of cancer chemodynamic therapy by targeting glutamine metabolism.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d2nr01736a
Abstract: The reprogrammed amino acid metabolism maintains the powerful antioxidant defense and DNA damage repair capacity of cancer cells, which could promote their escape from reactive oxygen species (ROS)-induced damage and inevitably diminish the efficacy of… read more here.
Keywords: metabolism; glutamine metabolism; zeolitic imidazolate; chemodynamic therapy ... See more keywords
Tumor-targeted nanoflowers regulate glutamine metabolism and amplify oxidative stress for synergistic therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc00487b
Abstract: We designed and synthesized tumor-targeted nanoflowers to inhibit glutamine metabolism and amplify oxidative stress, which could synergistically suppress tumor growth. read more here.
Keywords: targeted nanoflowers; glutamine metabolism; amplify oxidative; tumor targeted ... See more keywords