Targeting mTORC2/HDAC3 Inhibits Stemness of Liver Cancer Cells Against Glutamine Starvation
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202103887
Abstract: Cancer cells are addicted to glutamine. However, cancer cells often suffer from glutamine starvation, which largely results from the fast growth of cancer cells and the insufficient vascularization in the interior of cancer tissues. Herein,… read more here.
Keywords: cancer; liver cancer; glutamine starvation; hdac3 ... See more keywords
Abstract 3080: Activation of mTORC2/Akt is amplified during glutamine starvation and is mediated by GCN2
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-3080
Abstract: Highly proliferative cells like cancer cells depend on glucose and glutamine to augment flux through metabolic and biosynthetic pathways. The mechanistic target of rapamycin (mTOR) integrates signals from nutrients and other growth signals to maintain… read more here.
Keywords: cancer; mtorc2 akt; starvation; glutamine starvation ... See more keywords