Glutamine synthetase gene knockout-human embryonic kidney 293E cells for stable production of monoclonal antibodies.
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.26552
Abstract: Previously, it was inferred that a high glutamine synthetase (GS) activity in human embryonic kidney (HEK) 293E cells results in elevated resistance to methionine sulfoximine (MSX) and consequently hampers GS-mediated gene amplification and selection by… read more here.
Keywords: glutamine synthetase; 293e cells; embryonic kidney; hek293e ... See more keywords
Intrinsically disordered inhibitor of glutamine synthetase is a functional protein with random‐coil‐like pKa values
Sign Up to like & getrecommendations! Published in 2017 at "Protein Science"
DOI: 10.1002/pro.3157
Abstract: The sequential action of glutamine synthetase (GS) and glutamate synthase (GOGAT) in cyanobacteria allows the incorporation of ammonium into carbon skeletons. In the cyanobacterium Synechocystis sp. PCC 6803, the activity of GS is modulated by… read more here.
Keywords: protein; glutamine synthetase; random coil; pka values ... See more keywords
Lactobacillus crispatus and its enolase and glutamine synthetase influence interactions between Neisseria gonorrhoeae and human epithelial cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Microbiology"
DOI: 10.1007/s12275-020-9505-9
Abstract: Neisseria gonorrhoeae, an obligatory human pathogen causes the sexually transmitted disease gonorrhea, which remains a global health problem. N. gonorrhoeae primarily infects the mucosa of the genitourinary tract, which in women, is colonized by natural… read more here.
Keywords: epithelial cells; glutamine synthetase; enolase glutamine; neisseria gonorrhoeae ... See more keywords
Persistent Overexposure to N-Methyl-d-Aspartate (NMDA) Calcium-Dependently Downregulates Glutamine Synthetase, Aquaporin 4, and Kir4.1 Channel in Mouse Cortical Astrocytes
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicity Research"
DOI: 10.1007/s12640-018-9958-3
Abstract: Astrocytes express N-methyl-d-aspartate (NMDA) receptor (NMDAR) but its functions in these cells are not well defined. This study shows that the sustained exposure (8–72 h) of mouse astrocytes to NMDA decreases the expression of the functional… read more here.
Keywords: methyl aspartate; glutamine synthetase; kir4; aspartate nmda ... See more keywords
Novel aspects of glutamine synthetase in ammonia homeostasis
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2020.104809
Abstract: Elevated blood ammonia (hyperammonemia) is believed to be a major contributor to the neurological sequelae following severe liver disease. Ammonia is cleared via two main mechanisms, the urea cycle pathway and the glutamine synthetase reaction.… read more here.
Keywords: glutamine synthetase; ammonia homeostasis; urea cycle; synthetase reaction ... See more keywords
Antiepilepticus Effects of Tetrahedral Framework Nucleic Acid via Inhibition of Gliosis-Induced Downregulation of Glutamine Synthetase and Increased AMPAR Internalization in the Postsynaptic Membrane.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c00025
Abstract: More than 15 million out of 70 million patients worldwide do not respond to available antiepilepticus drugs (AEDs). With the emergence of nanomedicine, nanomaterials are increasingly being used to treat many diseases. Here, we report… read more here.
Keywords: downregulation glutamine; acid; tetrahedral framework; framework nucleic ... See more keywords
Transcriptional repressor IAA17 is involved in nitrogen use by modulating cytosolic glutamine synthetase GLN1;2 in Arabidopsis roots
Sign Up to like & getrecommendations! Published in 2017 at "Soil Science and Plant Nutrition"
DOI: 10.1080/00380768.2017.1314178
Abstract: ABSTRACT Nitrogen is an essential element for plant growth. Development of the root system architecture is highly correlated with nitrogen availability from the environment. Recent studies show that auxin response modules are involved in nitrate-dependent… read more here.
Keywords: nitrogen; glutamine synthetase; cytosolic glutamine; auxin signaling ... See more keywords
Diagnostic challenges of focal nodular hyperplasia: interobserver variability, accuracy, and the utility of glutamine synthetase immunohistochemistry
Sign Up to like & getrecommendations! Published in 2021 at "Histopathology"
DOI: 10.1111/his.14424
Abstract: The diagnosis of focal nodular hyperplasia (FNH) and the interpretation of glutamine synthetase (GS) staining can be challenging on biopsies. We aimed to evaluate the reproducibility of needle biopsy diagnosis of FNH, the effect of… read more here.
Keywords: nodular hyperplasia; focal nodular; glutamine synthetase; diagnosis ... See more keywords
Glutamine synthetase: an unlikely case of functional redundancy in Arabidopsis thaliana.
Sign Up to like & getrecommendations! Published in 2022 at "Plant biology"
DOI: 10.1111/plb.13408
Abstract: Glutamine synthetase (GS, EC 6.3.1.2) is an essential enzyme in plant metabolism, catalysing the assimilation of inorganic nitrogen into the amino acid glutamine. GS is a key enzyme in plant growth and has received special… read more here.
Keywords: plant; functional redundancy; redundancy; glutamine synthetase ... See more keywords
Inhibition of glutamine synthetase in monocytes from patients with acute-on-chronic liver failure resuscitates their antibacterial and inflammatory capacity
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DOI: 10.1136/gutjnl-2018-316888
Abstract: Objective Acute-on-chronic liver failure (ACLF) is associated with dysfunctional circulating monocytes whereby patients become highly susceptible to bacterial infections. Here, we identify the pathways underlying monocyte dysfunction in ACLF and we investigate whether metabolic rewiring… read more here.
Keywords: monocytes patients; glutamine synthetase; inflammatory capacity; capacity ... See more keywords
1,25-Dihydroxyvitamin D Regulation of Glutamine Synthetase and Glutamine Metabolism in Human Mammary Epithelial Cells
Sign Up to like & getrecommendations! Published in 2017 at "Endocrinology"
DOI: 10.1210/en.2017-00238
Abstract: Genomic profiling has identified a subset of metabolic genes that are altered by 1,25-dihydroxyvitamin D (1,25D) in breast cells, including GLUL, the gene that encodes glutamine synthetase (GS). In this study, we explored the relevance… read more here.
Keywords: epithelial cells; mammary epithelial; glutamine synthetase; human mammary ... See more keywords