Inhibition of Anaplerotic Glutaminolysis Underlies Selenite Toxicity in Human Lung Cancer
Sign Up to like & getrecommendations! Published in 2019 at "PROTEOMICS"
DOI: 10.1002/pmic.201800486
Abstract: Large clinical trials and model systems studies suggest that the chemical form of selenium dictates chemopreventive and chemotherapeutic efficacy. Selenite induces excess ROS production, which mediates autophagy and eventual cell death in non‐small cell lung… read more here.
Keywords: cancer; glutaminolysis; selenite toxicity; lung cancer ... See more keywords
Impairment of astrocytic glutaminolysis in glutaric aciduria type I
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Inherited Metabolic Disease"
DOI: 10.1007/s10545-017-0096-5
Abstract: Glutaric aciduria type I is a rare, autosomal recessive, inherited defect of glutaryl-CoA dehydrogenase. Deficiency of this protein in L-lysine degradation leads to the characteristic accumulation of nontoxic glutarylcarnitine and neurotoxic glutaric acid (GA), glutaryl-CoA,… read more here.
Keywords: glutaric aciduria; impairment astrocytic; aciduria type; astrocytic glutaminolysis ... See more keywords
Inhibition of glutaminolysis in combination with other therapies to improve cancer treatment.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2021.01.006
Abstract: Targeting glutamine catabolism has been attracting more research attention on the development of successful cancer therapy. Catalytic enzymes such as glutaminase (GLS) in glutaminolysis, a series of biochemical reactions by which glutamine is converted to… read more here.
Keywords: combination therapies; glutaminolysis combination; inhibition glutaminolysis; cancer ... See more keywords
Trans cohort metabolic reprogramming towards glutaminolysis in long-term successfully treated HIV-infection
Sign Up to like & getrecommendations! Published in 2022 at "Communications Biology"
DOI: 10.1038/s42003-021-02985-3
Abstract: Despite successful combination antiretroviral therapy (cART), persistent low-grade immune activation together with inflammation and toxic antiretroviral drugs can lead to long-lasting metabolic flexibility and adaptation in people living with HIV (PLWH). Our study investigated alterations… read more here.
Keywords: hiv; long term; hiv infection; glutaminolysis ... See more keywords
Activation of Piezo1 promotes osteogenic differentiation of aortic valve interstitial cell through YAP-dependent glutaminolysis.
Sign Up to like & getrecommendations! Published in 2023 at "Science advances"
DOI: 10.1126/sciadv.adg0478
Abstract: Hemodynamic overload and dysregulation of cellular metabolism are involved in development of calcific aortic valve disease (CAVD). However, how mechanical stress relates to metabolic changes in CAVD remains unclear. Here, we show that Piezo1, a… read more here.
Keywords: aortic valve; glutaminolysis; activation; osteogenic differentiation ... See more keywords
Mandarin Fish (Siniperca chuatsi) p53 Regulates Glutaminolysis Induced by Virus via the p53/miR145-5p/c-Myc Pathway in Chinese Perch Brain Cells
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02727-21
Abstract: Infectious spleen and kidney necrosis virus (ISKNV) and Siniperca chuatsi rhabdovirus (SCRV) as major causative agents have caused a serious threat to the mandarin fish farming industry (J.-J. Tao, J.-F. Gui, and Q.-Y. Zhang, Aquaculture… read more here.
Keywords: p53 mir145; siniperca chuatsi; glutaminolysis; p53 ... See more keywords
Keap1 Loss Drives Kras-Mutant Lung Cancer and Glutaminolysis Dependency.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2017-192
Abstract: Loss of Keap1 hyperactivates NRF2 to induce glutaminolysis-dependent Kras-driven lung cancer. read more here.
Keywords: lung cancer; keap1 loss; loss drives; cancer ... See more keywords
Abstract 517: Glutaminolysis is Required to Initiate Myofibroblast Differentiation and Persistence During Stress
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.517
Abstract: Cardiac fibrosis occurs in ischemic heart failure, genetic cardiomyopathies, diabetes, and aging. While initially considered reparative, resident cardiac fibroblasts (CFs) activation/differentiation to myofibroblasts provide contractile and integral support; however, persistent activation leads to progressive cardiac… read more here.
Keywords: myofibroblast; stress; differentiation; persistence ... See more keywords
Glutaminolysis Promotes Collagen Translation and Stability via &agr;‐Ketoglutarate‐mediated mTOR Activation and Proline Hydroxylation
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2017-0238oc
Abstract: Abstract Glutaminolysis is the metabolic process of glutamine, aberration of which has been implicated in several pathogeneses. Although we and others recently found a diversity of metabolic dysregulation in organ fibrosis, it is unknown if… read more here.
Keywords: agr; collagen translation; proline hydroxylation; translation stability ... See more keywords
Glutaminolysis gets the spotlight in cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14384
Abstract: The fact that cancer cells rewire their metabolism to meet their extreme energetic and biosynthetic needs has long been known, since the seminal studies by Otto Warburg demonstrated that cancer cells heavily rely on glycolysis… read more here.
Keywords: gls; glutaminase; metabolism; cancer cells ... See more keywords
Fungal dysbiosis facilitates inflammatory bowel disease by enhancing CD4+ T cell glutaminolysis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1140757
Abstract: The fungal microbiota is an important component of the complex multikingdom microbial community colonizing the mammalian gastrointestinal tract and has an important role in immune regulation. However, how fungi regulate inflammatory bowel disease (IBD) is… read more here.
Keywords: fungal dysbiosis; glutaminolysis; inflammatory bowel; bowel disease ... See more keywords