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   Articles with "glutamylation" as a keyword



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Glutamylation Regulates Transport, Specializes Function, and Sculpts the Structure of Cilia

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recommendations! Published in 2017 at "Current Biology"

DOI: 10.1016/j.cub.2017.09.066

Abstract: Ciliary microtubules (MTs) are extensively decorated with post-translational modifications (PTMs), such as glutamylation of tubulin tails. PTMs and tubulin isotype diversity act as a "tubulin code" that regulates cytoskeletal stability and the activity of MT-associated… read more here.

Keywords: microscopy; tubulin code; function; kinesin ... See more keywords
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Glutaminase-catalyzed γ-glutamylation to produce CCK secretion-stimulatory γ-[Glu]n-Trp peptides superior to tryptophan

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recommendations! Published in 2019 at "Journal of Functional Foods"

DOI: 10.1016/j.jff.2019.103418

Abstract: Abstract This study follows recent attempts to discover and improve the effectiveness of dietary peptides as stimulators of cholecystokinin (CCK) secretion. This study is the first report about the effect of γ-[Glu](n=1,2,3,4)-Trp, produced via γ-glutamylation… read more here.

Keywords: cck secretion; glutamylation; glu trp; trp ... See more keywords
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Glutamylation of Bacterial Ubiquitin Ligases by a Legionella Pseudokinase.

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recommendations! Published in 2019 at "Trends in microbiology"

DOI: 10.1016/j.tim.2019.09.001

Abstract: Legionella pneumophila encodes a family of phosphoribosyl ubiquitination ligases (SidE) essential for the bacterium to establish successful infection. Four independent studies now show that the SidE family of ubiquitin ligases are regulated by a novel… read more here.

Keywords: ligases legionella; bacterial ubiquitin; ubiquitin ligases; glutamylation bacterial ... See more keywords

Structural basis for protein glutamylation by the Legionella pseudokinase SidJ.

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recommendations! Published in 2021 at "Nature communications"

DOI: 10.1038/s41467-021-26429-y

Abstract: Legionella pneumophila (LP) avoids phagocytosis by secreting nearly 300 effector proteins into the host cytosol. SidE family of effectors (SdeA, SdeB, SdeC and SidE) employ phosphoribosyl ubiquitination to target multiple host Rab GTPases and innate… read more here.

Keywords: sdea; legionella; protein glutamylation; pseudokinase sidj ... See more keywords
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Impaired glutamylation of RPGRORF15 underlies the cone-dominated phenotype associated with truncating distal ORF15 variants

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2208707119

Abstract: Significance Retinitis pigmentosa GTPase regulator (RPGR) disease variants lead to considerable phenotypic heterogeneity in terms of relative involvement of rod and cone photoreceptors. We have identified a clear progressive shift from rod- to cone-dominating phenotypes… read more here.

Keywords: dominated phenotype; cone dominated; glutamylation; truncating distal ... See more keywords