Iron‐sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia
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DOI: 10.1002/glia.23178
Abstract: Demyelinated brain lesions, a hallmark of autoimmune neuroinflammatory diseases like multiple sclerosis, result from oligodendroglial cell damage. Activated microglia are considered a major source of nitric oxide and subsequent peroxynitrite‐mediated damage of myelin. Here, we… read more here.
Keywords: iron sulfur; glutaredoxin; activated microglia; damage ... See more keywords
Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects.
Sign Up to like & getrecommendations! Published in 2019 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2018.11.013
Abstract: Peroxiredoxin 1 (Prx1) and glutaredoxin 3 (Grx3) are two major antioxidant proteins that play a critical role in maintaining redox homeostasis for tumor progression. Here, we identify the prototypical pyranonaphthoquinone natural product frenolicin B (FB)… read more here.
Keywords: bp1; glutaredoxin; prx1 grx3; frenolicin targets ... See more keywords
Glutaredoxin-1 control on liver fibrosis in aged mice
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DOI: 10.1016/j.freeradbiomed.2017.10.079
Abstract: Objective Glutaredoxin-1 (Glrx) is a cytosolic enzyme which removes glutathione (GSH) adducts of protein thiols (S-glutathionylation), and controls protein functions including cellular signaling and gene transcription. We previously showed that Glrx knockout middle-aged mice developed… read more here.
Keywords: aged mice; glutaredoxin; glrx; liver fibrosis ... See more keywords
Glutaredoxin 2 promotes SP-1-dependent CSPG4 transcription and migration of wound healing NG2 glia and glioma cells: Enzymatic Taoism.
Sign Up to like & getrecommendations! Published in 2021 at "Redox biology"
DOI: 10.1016/j.redox.2021.102221
Abstract: Redox regulation of specific cysteines via oxidoreductases of the thioredoxin family is increasingly being recognized as an important signaling pathway. Here, we demonstrate that the cytosolic isoform of the vertebrate-specific oxidoreductase Glutaredoxin 2 (Grx2c) regulates… read more here.
Keywords: migration wound; enzymatic taoism; transcription; wound healing ... See more keywords
Redox Modification of the Iron-Sulfur Glutaredoxin GRXS17 Activates Holdase Activity and Protects Plants from Heat Stress.
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DOI: 10.1104/pp.20.00906
Abstract: Heat stress induces misfolding and aggregation of proteins unless they are guarded by chaperone systems. Here, we examined the function of the glutaredoxin GRXS17, a member of thiol reductase families in the model plant Arabidopsis… read more here.
Keywords: heat stress; glutaredoxin; stress; heat ... See more keywords
Loss and Recovery of Glutaredoxin 5 Is Inducible by Diet in a Murine Model of Diabesity and Mediated by Free Fatty Acids In Vitro
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DOI: 10.3390/antiox11040788
Abstract: Free fatty acids (FFA), hyperglycemia, and inflammatory cytokines are major mediators of β-cell toxicity in type 2 diabetes mellitus, impairing mitochondrial metabolism. Glutaredoxin 5 (Glrx5) is a mitochondrial protein involved in the assembly of iron–sulfur… read more here.
Keywords: diabesity; loss; fatty acids; glrx5 ... See more keywords
Administration of Glutaredoxin-1 Attenuates Liver Fibrosis Caused by Aging and Non-Alcoholic Steatohepatitis
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DOI: 10.3390/antiox11050867
Abstract: Liver fibrosis is a sign of non-alcoholic fatty liver disease progression towards steatohepatitis (NASH) and cirrhosis and is accelerated by aging. Glutaredoxin-1 (Glrx) controls redox signaling by reversing protein S-glutathionylation, induced by oxidative stress, and… read more here.
Keywords: liver fibrosis; non alcoholic; glrx; glutaredoxin ... See more keywords
Expression Analysis of a Novel Oxidoreductase Glutaredoxin 2 in Black Tiger Shrimp, Penaeus monodon
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DOI: 10.3390/antiox11101857
Abstract: Glutaredoxin (Grx) is a glutathione-dependent oxidoreductase that is an important component of the redox system in organisms. However, there is a serious lack of sequence information and functional validation related to Grx in crustaceans. In… read more here.
Keywords: oxidoreductase; penaeus monodon; glutaredoxin; expression ... See more keywords
Protein Glutathionylation and Glutaredoxin: Role in Neurodegenerative Diseases
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DOI: 10.3390/antiox11122334
Abstract: Oxidative stress has been implicated in the pathogenesis and progression of many neurodegenerative disorders including Parkinson’s disease and Alzheimer’s disease. One of the major enzyme systems involved in the defense against reactive oxygen species are… read more here.
Keywords: glutathione glutaredoxin; glutaredoxin; role; brain ... See more keywords