A novel method for Identification of Glutarylation sites combining Borderline-SMOTE with Tomek links technique in imbalanced data.
Sign Up to like & getrecommendations! Published in 2021 at "IEEE/ACM transactions on computational biology and bioinformatics"
DOI: 10.1109/tcbb.2021.3095482
Abstract: Glutarylation is a type of post-translational modification that occurs on lysine residues. It plays an irreplaceable role in various cellular functions. Therefore, identification of glutarylation sites is significant for understanding the molecular mechanism of glutarylation.… read more here.
Keywords: identification glutarylation; glutarylation; links technique; tomek links ... See more keywords
Functions and Mechanisms of Lysine Glutarylation in Eukaryotes
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.667684
Abstract: Lysine glutarylation (Kglu) is a newly discovered post-translational modification (PTM), which is considered to be reversible, dynamic, and conserved in prokaryotes and eukaryotes. Recent developments in the identification of Kglu by mass spectrometry have shown… read more here.
Keywords: glutarylation eukaryotes; mechanisms lysine; functions mechanisms; lysine glutarylation ... See more keywords
ProtTrans-Glutar: Incorporating Features From Pre-trained Transformer-Based Models for Predicting Glutarylation Sites
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.885929
Abstract: Lysine glutarylation is a post-translational modification (PTM) that plays a regulatory role in various physiological and biological processes. Identifying glutarylated peptides using proteomic techniques is expensive and time-consuming. Therefore, developing computational models and predictors can… read more here.
Keywords: prottrans glutar; trained transformer; glutarylation sites; transformer based ... See more keywords
Preparation of Affinity Purified Antibodies against ε-Glutaryl-Lysine Residues in Proteins for Investigation of Glutarylated Proteins in Animal Tissues
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DOI: 10.3390/biom11081168
Abstract: The glutarylation of lysine residues in proteins attracts attention as a possible mechanism of metabolic regulation, perturbed in pathologies. The visualization of protein glutarylation by antibodies specific to ε-glutaryl-lysine residues may be particularly useful to… read more here.
Keywords: glutarylated proteins; glutarylation; glutaryl lysine; lysine residues ... See more keywords
Deep Neural Network Framework Based on Word Embedding for Protein Glutarylation Sites Prediction
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12081213
Abstract: In recent years, much research has found that dysregulation of glutarylation is associated with many human diseases, such as diabetes, cancer, and glutaric aciduria type I. Therefore, glutarylation identification and characterization are essential tasks for… read more here.
Keywords: sites prediction; deep neural; glutarylation sites; word embedding ... See more keywords