Structure and steroid isomerase activity of Drosophila glutathione transferase E14 essential for ecdysteroid biosynthesis
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13718
Abstract: Ecdysteroids are critically important for the formation of the insect exoskeleton. Cholesterol is a precursor of ecdysone and its active form 20‐hydroxyecdysone, but some steps in the ecdysteroid biosynthesis pathway remain unknown. An essential requirement… read more here.
Keywords: isomerase activity; biosynthesis; transferase; ecdysteroid biosynthesis ... See more keywords
An Ultrasmall SnFe2O4 Nanozyme with Endogenous Oxygen Generation and Glutathione Depletion for Synergistic Cancer Therapy
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DOI: 10.1002/adfm.202006216
Abstract: The tumor microenvironment (TME) with the characteristics of severe hypoxia, overexpressed glutathione (GSH), and high levels of hydrogen peroxide (H2O2) dramatically limits the antitumor efficiency by monotherapy. Herein, a novel TME‐modulated nanozyme employing tin ferrite… read more here.
Keywords: ultrasmall snfe2o4; therapy; oxygen; glutathione ... See more keywords
Nanocatalytic Theranostics with Glutathione Depletion and Enhanced Reactive Oxygen Species Generation for Efficient Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202006892
Abstract: Chemodynamic therapy (CDT) is an emerging therapy method that kills cancer cells by converting intracellular hydrogen peroxide (H2 O2 ) into highly toxic hydroxyl radicals (• OH). To overcome the current limitations of the insufficient… read more here.
Keywords: nanocatalytic theranostics; cancer therapy; cancer; therapy ... See more keywords
Glutathione‐Depleting Organic Metal Adjuvants for Effective NIR‐II Photothermal Immunotherapy
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DOI: 10.1002/adma.202201706
Abstract: Although photothermal immunotherapy (PTI) is a compelling strategy for tumor therapy, the development of promising photothermal agents to overcome the insufficient immunogenicity of tumor cells and the poor immune response encountered in PTI is still… read more here.
Keywords: photothermal immunotherapy; metal adjuvants; organic metal; glutathione ... See more keywords
The effect of brimonidine and proparacaine on metabolic enzymes: Glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2107
Abstract: Oxidative stress is to upregulate the pentose phosphate pathway (PPP). The PPP consists of two functionally branches, glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD). Glutathione reductase (GR) has a significant role in catalyzing an oxidized… read more here.
Keywords: dehydrogenase; phosphate dehydrogenase; glucose phosphate; brimonidine proparacaine ... See more keywords
Efficient production of glutathione in Saccharomyces cerevisiae via a synthetic isozyme system
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Journal"
DOI: 10.1002/biot.202200398
Abstract: Glutathione, a tripeptide consisting of cysteine, glutamic acid, and glycine, has multiple beneficial effects on human health. Previous studies have focused on producing glutathione in Saccharomyces cerevisiae by overexpressing γ‐glutamylcysteine synthetase (GSH1) and glutathione synthetase… read more here.
Keywords: system; production; glutathione; synthetic isozyme ... See more keywords
Glutathione and thioredoxin systems contribute to recombinant monoclonal antibody interchain disulfide bond reduction during bioprocessing
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26278
Abstract: Antibody interchain disulfide bond reduction during biopharmaceutical manufacturing has received increased attention since it was first reported in 2010. Antibody reduction leads to loss of product and reduced product stability. It is therefore critical to… read more here.
Keywords: reduction; system; antibody; thioredoxin ... See more keywords
Isotopically Labeled Clickable Glutathione to Quantify Protein S‐Glutathionylation
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DOI: 10.1002/cbic.201900528
Abstract: Protein S‐glutathionylation is one of the important cysteine oxidation events that regulate various redox‐mediated biological processes. Despite several existing methods, there are few proteomic approaches to identify and quantify specific cysteine residues susceptible to S‐glutathionylation.… read more here.
Keywords: glutathionylation; labeled clickable; protein glutathionylation; isotopically labeled ... See more keywords
Efficacious Doxorubicin Delivery Using Glutathione‐Responsive Hollow Non‐phospholipid Vesicles Bearing Lipoyl Cholesterols
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DOI: 10.1002/cmdc.201900335
Abstract: In this study, we developed redox‐sensitive vesicles using synthesised lipoyl cholesterol derivatives, a non‐ionic surfactant and an optimum level of free cholesterol. Interestingly, concentration‐dependent self‐assembly was observed by scanning electron microscopy, wherein vesicles manifested as… read more here.
Keywords: efficacious doxorubicin; drug; doxorubicin delivery; delivery using ... See more keywords
Cyclic Octapeptides Composed of Two Glutathione Units Outperform the Monomer in Lead Detoxification
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DOI: 10.1002/cmdc.202200152
Abstract: A rationally‐designed scaffold of cyclic octapeptides composed of two units of the natural tripeptide glutathione (GSH) was optimized to strongly and selectively capture toxic lead ions (Pb(II)). Using state‐of‐the‐art computational tools, a list of eleven… read more here.
Keywords: detoxification; octapeptides composed; cyclic octapeptides; glutathione ... See more keywords
Determination of glutathione in blood via capillary electrophoresis with pH‐mediated stacking
Sign Up to like & getrecommendations! Published in 2022 at "ELECTROPHORESIS"
DOI: 10.1002/elps.202200119
Abstract: A new approach has been developed for the direct determination of reduced (glutathione [GSH]) and oxidized (glutathione disulfide [GSSG]) GSH in whole blood by means of capillary electrophoresis. Its features include GSH‐stabilizing sample preparation, the… read more here.
Keywords: mediated stacking; determination; blood; glutathione ... See more keywords