Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation
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DOI: 10.1038/ncomms14844
Abstract: TP53, a critical tumour suppressor gene, is mutated in over half of all cancers resulting in mutant-p53 protein accumulation and poor patient survival. Therapeutic strategies to target mutant-p53 cancers are urgently needed. We show that… read more here.
Keywords: p53 protein; system; mutant p53; glutathione axis ... See more keywords