Identifying Cysteine, N-Acetylcysteine, and Glutathione-Conjugates as Novel Metabolites of Aristolochic Acid I: Emergence of a New Detoxification Pathway.
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DOI: 10.1021/acs.chemrestox.9b00488
Abstract: There is accumulating evidence that Balkan endemic nephropathy (BEN) is an environmental disease caused by aristolochic acids (AAs) released from the decomposition of Aristolochia clematitis L., an AA-containing weed that grows abundantly in the Balkan… read more here.
Keywords: acetylcysteine glutathione; cysteine acetylcysteine; detoxification; identifying cysteine ... See more keywords
Characterization of glutathione conjugates derived from reactive metabolites of seven silymarin isomers
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DOI: 10.1080/00498254.2018.1549340
Abstract: Abstract 1. Silymarin refers to a class of flavonoid lignans occurring in the fruits and seeds of the Silybum manalttlm (L). Gaertn, and is widely used in dietary supplements. 2. The main active ingredients of… read more here.
Keywords: glutathione conjugates; characterization glutathione; reactive metabolites; silymarin isomers ... See more keywords