Glutathione-depletion mesoporous organosilica nanoparticles as a self-adjuvant and Co-delivery platform for enhanced cancer immunotherapy.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.05.025
Abstract: Silica based nanoparticles have emerged as a promising vaccine delivery system for cancer immunotherapy, but their bio-degradability, adjuvanticity and the resultant antitumor activity remain to be largely improved. In this study, we report biodegradable glutathione-depletion… read more here.
Keywords: mesoporous organosilica; delivery; glutathione depletion; cancer immunotherapy ... See more keywords
Glutathione Depletion Disrupts Redox Homeostasis in an Anoxia-Tolerant Invertebrate
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DOI: 10.3390/antiox12061197
Abstract: The upregulation of endogenous antioxidants is a widespread phenomenon in animals that tolerate hypoxia/anoxia for extended periods. The identity of the mobilized antioxidant is often context-dependent and differs among species, tissues, and stresses. Thus, the… read more here.
Keywords: glutathione depletion; glutathione; redox homeostasis; anoxia ... See more keywords
Quercetin-Induced Glutathione Depletion Sensitizes Colorectal Cancer Cells to Oxaliplatin
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DOI: 10.3390/foods12081733
Abstract: Quercetin is an antioxidant phytochemical which belongs to the natural flavonoids group. Recently, the compound has been reported to inhibit glutathione reductase responsible for replenishing reduced forms of glutathione and thus leads to glutathione depletion,… read more here.
Keywords: glutathione depletion; glutathione; cancer cells; quercetin ... See more keywords