Synthesis of Glutathione (GSH)-Responsive Amphiphilic Duplexes and their Application in Gene Delivery.
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DOI: 10.1002/cplu.201900295
Abstract: Oligoamide molecular strands with hydrogen-bonding sequences DADDAD and guanidine (O-1) or 1,5,9-triazacyclododecane ([12]aneN3 ; O-2) side chains and oligoamides with hydrogen-bonding sequences ADAADA and octyl moieties (O-3), were synthesized. Two duplexes (D-1 and D-2) were… read more here.
Keywords: synthesis glutathione; glutathione gsh; gsh responsive; responsive amphiphilic ... See more keywords
Extensive Molecular Dynamics Simulations Disclosed the Stability of mPGES‐1 Enzyme and the Structural Role of Glutathione (GSH) Cofactor
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DOI: 10.1002/minf.202200140
Abstract: A deep in silico investigation of various microsomal prostaglandin E2 synthase‐1 (mPGES‐1) protein systems is here reported using molecular dynamics (MD) simulations. Firstly, eight different proteins models (Models A−H) were built, starting from the active… read more here.
Keywords: dynamics simulations; gsh; role; molecular dynamics ... See more keywords
Mycorrhizal Colonization Enhanced Sorghum bicolor Tolerance under Soil Water Deficit Conditions by Coordination of Proline and Reduced Glutathione (GSH).
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c07184
Abstract: Drought stress is an important limiting factor in crop production. Arbuscular mycorrhizal fungi (AMF) enhance plant drought tolerance through antioxidant activities. However, the coordination of nonenzymatic antioxidants against drought remains unclear. Here, we investigated the… read more here.
Keywords: proline; glutathione gsh; tolerance; sorghum bicolor ... See more keywords
Systematic Study of the Glutathione (GSH) Reactivity of N-Phenylacrylamides: 2. Effects of Acrylamide Substitution.
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DOI: 10.1021/acs.jmedchem.0c00749
Abstract: A comprehensive understanding of structure-reactivity relationships is critical to the design and optimization of cysteine-targeted covalent inhibitors. Herein we report glutathione (GSH) reaction rates for N-phenyl acrylamides with varied substitutions at the - and -… read more here.
Keywords: reactivity; gsh reactivity; glutathione gsh; systematic study ... See more keywords
The Precursor to Glutathione (GSH), γ-Glutamylcysteine (GGC), Can Ameliorate Oxidative Damage and Neuroinflammation Induced by Aβ40 Oligomers in Human Astrocytes
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2019.00177
Abstract: Glutathione (GSH) is one of the most abundant thiol antioxidants in cells. Many chronic and age-related diseases are associated with a decline in cellular GSH levels or impairment in the catalytic activity of the GSH… read more here.
Keywords: gsh; human astrocytes; glutathione gsh; ggc ... See more keywords