Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-01706-0
Abstract: Glutathione (GSH) is an important antioxidant that plays a critical role in neuroprotection. GSH depletion in neurons induces oxidative stress and thereby promotes neuronal damage, which in turn is regarded as a hallmark of the… read more here.
Keywords: glutathione levels; mir; expression; gtrap3 ... See more keywords
Relationships among Cortical Glutathione Levels, Brain Amyloidosis, and Memory in Healthy Older Adults Investigated In Vivo with 1H-MRS and Pittsburgh Compound-B PET
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Neuroradiology"
DOI: 10.3174/ajnr.a5143
Abstract: BACKGROUND AND PURPOSE: Oxidative stress has been implicated as an important pathologic mechanism in the development of Alzheimer disease. The purpose of this study was to assess whether glutathione levels, detected noninvasively with proton MR… read more here.
Keywords: spectroscopy; glutathione levels; brain amyloidosis; glutathione ... See more keywords
Low tumor glutathione level as a sensitivity marker for glutamate-cysteine ligase inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "Oncology letters"
DOI: 10.3892/ol.2018.8447
Abstract: Previous metabolomic analyses of cancer have revealed elevated glutathione levels in tumors. An inhibitor of cystine uptake was identified to suppress glutathione biosynthesis, leading to ferroptosis, a novel iron-dependent form of cell death that differs… read more here.
Keywords: glutathione levels; bso; sensitivity; ferroptosis ... See more keywords