Rational Optimization of Dihydropyrimidinone‐Quinoline Hybrids as Plasmodium falciparum Glutathione Reductase Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200034
Abstract: A series of dihydropyrimidinone‐based antimalarial compounds were designed and synthesised based on the previously identified amide‐based quinoline hybrids which showed good resistance reversal ability against the resistant strain of Plasmodium falciparum. The aromatic ring on… read more here.
Keywords: plasmodium falciparum; glutathione reductase; dihydropyrimidinone; falciparum glutathione ... See more keywords
Inhibition of Glutathione Reductase Activity from Baker’s Yeast (Saccharomyces cerevisiae) By Copper(II) Oxide Nanoparticles and Copper(II) Chloride
Sign Up to like & getrecommendations! Published in 2021 at "Bulletin of Environmental Contamination and Toxicology"
DOI: 10.1007/s00128-021-03136-4
Abstract: In this study, glutathione reductase (GR) from baker’s yeast (Saccharomyces cerevisiae) was exposed to 0, 25, 50, 100, 250 and 500 mg/L copper(II) oxide nanoparticles (CuO NPs) and copper(II) chloride (CuCl2). Changes in GR% activity… read more here.
Keywords: yeast saccharomyces; saccharomyces cerevisiae; baker yeast; glutathione reductase ... See more keywords
Role of the glutaredoxin domain and FAD in the stabilization of thioredoxin glutathione reductase.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.09.002
Abstract: Thioredoxin glutathione reductase (TGRsec) is a multi-domain flavoprotein that plays a principal role in redox homeostasis maintenance. We have previously demonstrated the role of selenocysteine in maintaining TGRsec structure-function, but the role of the glutaredoxin… read more here.
Keywords: domain fad; glutathione reductase; role; grx domain ... See more keywords
Effects of vernonia amygdalina fractionate on glutathione reductase and glutathione-S-transferase on alloxan induced diabetes wistar rat
Sign Up to like & getrecommendations! Published in 2021 at "Biocatalysis and agricultural biotechnology"
DOI: 10.1016/j.bcab.2021.102118
Abstract: Abstracts This research was conducted to examine the effect of vernonia amygdalina on Glutathione reductase and Glutathione-S-transferase in alloxan induced diabetic wistar rats. Sixty-six (66) adult male wistar rats weighing between 100 and 250 g were… read more here.
Keywords: glutathione reductase; vernonia amygdalina; glutathione; alloxan ... See more keywords
Involvement of glyoxalases and glutathione reductase in conferring abiotic stress tolerance to Jatropha curcas L.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental and Experimental Botany"
DOI: 10.1016/j.envexpbot.2016.11.011
Abstract: Abstract In the current study, we characterized three crucial enzymes, glyoxalase I, II (JcGLYI, JcGLYII) and glutathione reductase (JcGR) that are known to play key role in metabolite degradation and oxidative stress tolerance. Methylglyoxal (MG)… read more here.
Keywords: glutathione reductase; stress; stress tolerance; abiotic stress ... See more keywords
Understanding role of Glutathione Reductase gene family in drought and heat stresses in Brassica juncea and B. rapa
Sign Up to like & getrecommendations! Published in 2021 at "Environmental and Experimental Botany"
DOI: 10.1016/j.envexpbot.2021.104595
Abstract: Abstract In the era of global environmental changes, high curiosity in identifying and characterizing new antioxidant enzymes in plants has been witnessed. Previous studies reported the pivotal role played by Glutathione reductase (GR) in maintaining… read more here.
Keywords: glutathione reductase; juncea rapa; gene family; brassica juncea ... See more keywords
Synthesis, characterization, DFT studies of piperazine derivatives and its Ni(II), Cu(II) complexes as antimicrobial agents and glutathione reductase inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2018.06.076
Abstract: Abstract 1,4-Piperazinediacetic acid and 1,4-diethyl ester (1) were prepared by treating 1,4-piperazine with ethylchloroacetate; and its structure was identified by single crystal X-ray diffraction analysis. Then, 1,4-piperazinediacetic acid, 1,4-dihydrazide (2) and its metal complexes (2-Ni(II)… read more here.
Keywords: reductase; dft studies; glutathione reductase; characterization dft ... See more keywords
The In Vitro and In Silico Inhibition Mechanism of Glutathione Reductase by Resorcinol Derivatives: A Molecular Docking Study
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.129790
Abstract: Abstract Glutathione reductase (GR), which is a major antioxidant enzyme, is targeted in the treatment of many diseases due to the dual role of its product, reduced glutathione (GSH), in infected cells. This study's goal… read more here.
Keywords: resorcinol derivatives; inhibition; glutathione reductase; vitro silico ... See more keywords
Descriptive Analysis of Transient-State Observations for Thioredoxin/Glutathione Reductase (Sec597Cys) from Schistosoma mansoni.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.3c00051
Abstract: Thioredoxin/glutathione reductase from Schistosoma mansoni (SmTGR) catalyzes the reduction of both oxidized thioredoxin and glutathione with electrons from reduced nicotinamide adenine dinucleotide phosphate (NADPH). SmTGR is a drug target for the treatment of Schistosomiasis, an… read more here.
Keywords: schistosoma mansoni; glutathione reductase; thioredoxin glutathione;
Potent Inhibitors of Thioredoxin Glutathione Reductase: Grail of Anti-Schistosome Drug within Reach?
Sign Up to like & getrecommendations! Published in 2020 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.0c00072
Abstract: Species of the blood fluke Schistosoma are responsible for schistosomiasis, the second most common parasitic disease, which is prevalent particularly in poor communities. Under redox pressure, schistosomes survive in mammalian hosts with the help of… read more here.
Keywords: thioredoxin glutathione; inhibitors thioredoxin; glutathione reductase; drug ... See more keywords
Characterisation of naturally occurring isothiocyanates as glutathione reductase inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2020.1822828
Abstract: Abstract Glutathione reductase (GR), an essential antioxidant enzyme against oxidative stress, has become an attractive drug target for the development of anticancer and antimalarial drugs. In this regard, we evaluated the naturally occurring isothiocyanates as… read more here.
Keywords: isothiocyanates glutathione; occurring isothiocyanates; glutathione reductase; naturally occurring ... See more keywords