Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.06.003
Abstract: The enzyme glutaminase (GLS1) is currently in clinical trials for oncology, yet there are no clear diagnostic criteria to identify responders. The evaluation of 25 basal breast lines expressing GLS1, predominantly through its splice isoform… read more here.
Keywords: pan cancer; cancer metabolic; novo glutathione; glutathione synthesis ... See more keywords
A Systematic Review of the Various Effect of Arsenic on Glutathione Synthesis In Vitro and In Vivo
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DOI: 10.1155/2020/9414196
Abstract: Background Arsenic is a toxic metalloid widely present in nature, and arsenic poisoning in drinking water is a serious global public problem. Glutathione is an important reducing agent that inhibits arsenic-induced oxidative stress and participates… read more here.
Keywords: glutathione synthesis; effect arsenic; smd; vitro ... See more keywords