Glutathione S-transferases deletions may act as prognosis and therapeutic markers in breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-017-0461-6
Abstract: Breast cancer (BC) is the main worldwide neoplasia in women. The metabolic balance between xenobiotic absorption and elimination rates plays an important role in preventing DNA damage and, consequently, tumor development. The glutathione S-transferases (GSTs),… read more here.
Keywords: cancer; recurrence risk; glutathione transferases; breast cancer ... See more keywords
Using Chou’s Five-steps Rule to Classify and Predict Glutathione S-transferases with Different Machine Learning Algorithms and Pseudo Amino Acid Composition
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-020-10087-7
Abstract: The Glutathione S-Transferases (GSTs) are detoxification enzymes which exist in variety of living organisms such as bacteria, fungi, plants and animals. These multifunctional enzymes play important roles in the biosynthesis of steroids, prostaglandins, apoptosis regulation,… read more here.
Keywords: machine; amino acid; using chou; pseudo amino ... See more keywords
Overcoming resistance to cisplatin by inhibition of glutathione S-transferases (GSTs) with ethacraplatin micelles in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.08.021
Abstract: Platinum-based DNA-adducting agents are used extensively in the clinic for cancer chemotherapy. However, the anti-tumor efficacy of these drugs is severely limited by cisplatin resistance, and this can lead to the failure of chemotherapy. One… read more here.
Keywords: vitro vivo; overcoming resistance; cisplatin; resistance ... See more keywords
The role of glutathione S-transferases (GSTs) in insecticide resistance in crop pests and disease vectors.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in insect science"
DOI: 10.1016/j.cois.2018.04.007
Abstract: Insecticide resistance seriously threatens efficient arthropod pest management. Arthropod glutathione S-transferases (GSTs) confer resistance via direct metabolism or sequestration of chemicals, but also indirectly by providing protection against oxidative stress induced by insecticide exposure. To… read more here.
Keywords: resistance; role; glutathione transferases; insecticide resistance ... See more keywords
Identification and characterization of glutathione S-transferases and their potential roles in detoxification of abamectin in the rice stem borer, Chilo suppressalis.
Sign Up to like & getrecommendations! Published in 2022 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2022.105050
Abstract: The glutathione S-transferases (GSTs) are a kind of metabolic enzymes and participate in the detoxification metabolism of xenobiotics in various organisms. In insects, GSTs play important roles in the development of insecticide resistance and antioxidant… read more here.
Keywords: glutathione transferases; detoxification; rice; suppressalis ... See more keywords
“Plant Glutathione S-transferases: An overview”
Sign Up to like & getrecommendations! Published in 2020 at "Plant Gene"
DOI: 10.1016/j.plgene.2020.100233
Abstract: Summary Glutathione S-transferases (GST) belong to a super-family of multifunctional proteins and are one of the most important families of detoxifying enzymes in nature. There are involved in diverse intracellular events such as, primary and… read more here.
Keywords: plant; transferases overview; glutathione transferases; development ... See more keywords
Glutathione S-Transferases Mediate In Vitro and In Vivo Inactivation of Genipin: Implications for an Underlying Detoxification Mechanism.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c08175
Abstract: Genipin (GP), the reactive metabolite of geniposide (GE), is responsible for GE-induced hepatotoxicity. As a potential detoxification pathway, the inactivation of GP by glutathione S-transferases (GSTs) has not yet been characterized. In this study, the… read more here.
Keywords: vitro vivo; detoxification; genipin; glutathione transferases ... See more keywords
Fungal Glutathione Transferases as Tools to Explore the Chemical Diversity of Amazonian Wood Extractives
Sign Up to like & getrecommendations! Published in 2018 at "ACS Sustainable Chemistry & Engineering"
DOI: 10.1021/acssuschemeng.8b02636
Abstract: The natural durability of wood is linked to its chemical composition and in particular the presence of metabolites called extractives that often possess chemical reactivity. For dealing with these compounds, wood degraders have developed detoxification… read more here.
Keywords: fungal glutathione; wood extracts; tools explore; transferases tools ... See more keywords
Role of human glutathione transferases in biotransformation of the nitric oxide prodrug JS-K
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-00327-1
Abstract: Nitric oxide (NO) plays a prominent physiological role as a low-molecular-mass signal molecule involved in diverse biological functions. Great attention has been directed to pharmacologically modulating the release of NO for various therapeutic applications. We… read more here.
Keywords: human glutathione; role human; glutathione transferases; role ... See more keywords
Fluorescence detection of glutathione S-transferases in a low GSH level environment.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc02702e
Abstract: Glutathione S-transferases (GSTs) play crucial roles in the detoxification process and the development of drug-resistance and are proved to be important markers for various tumors. Different from the previous probes, we developed a fluorescent probe… read more here.
Keywords: detection; low gsh; level environment; gsh level ... See more keywords
Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc05278d
Abstract: Most of the known senolytics are anti-cancer drugs or their derivative molecules. However, senolytics derived from the active ingredients of traditional Chinese medicine (TCM) are rarely reported. Here, we identified oridonin as a novel senolytic… read more here.
Keywords: ros p38; glutathione transferases; activate ros; transferases activate ... See more keywords